Offering Prenatal Screening in the Age of Genomic Medicine: A Practical Guide

Megan Allyse, Umut Aypar, Natasha Bonhomme, Sandra Darilek, Michael Dougherty, Ruth Farrell, Wayne Grody, W. Edward Highsmith, Marsha Michie, Mark Nunes, Laura Otto, Rebecca Pabst, Glenn Palomaki, Cassandra Runke, Richard R. Sharp, Brian Skotko, Katie Stoll, Myra Wick

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Aims: In September, 2015, Mayo Clinic convened a panel of national thought leaders on prenatal screening, medical genetics, and obstetrics and gynecology practice. Results: During the 2-day symposium, participants discussed the implications of the shift toward broader prenatal screening using cell-free placental DNA in maternal serum (cfDNA screening). Key topics included challenges around the pace of change in the prenatal screening market, uncertainty around reimbursement, meeting the need for patient counseling, and potential challenges in interpreting and returning cfDNA screening results. Innovation: Here, we describe the challenges discussed and offer clinical recommendations for practices who are working to meet them. Conclusion: As the spread of prenatal genetic screening continues, providers will increasingly need to update their practice to accommodate new screening modalities.

Original languageEnglish (US)
Pages (from-to)755-761
Number of pages7
JournalJournal of Women's Health
Issue number7
StatePublished - Jul 2017


  • Prenatal care
  • genetic testing
  • prenatal counseling

ASJC Scopus subject areas

  • Medicine(all)


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