TY - JOUR
T1 - Oestrogens regulate divergent effects of prolactin in the ovary
AU - Veldhuis, Johannes D.
AU - Hammond, James M.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1980
Y1 - 1980
N2 - Prolactin exerts well established stimulatory effects both in vitro and in vivo in the rat ovary1. However, in the ovary of higher mammals, prolactin action is not well characterised, and may differ from that observed in rodents2. For example, in human clinical conditions of physiological or pathological prolactin excess, ovarian function is depressed3, and in isolated, human granulosa cells in vitro, prolactin seems to inhibit progesterone production4. To examine direct prolactin effects in the higher mammalian ovary, we have used an in vitro porcine granulosa-cell model5. In this system, prolactin action is bipotential, depending critically on the degree of granulosa-cell differentiation attained in vivo. Prolactin suppresses steroid production by cultured granulosa cells isolated from small (1-2 mm), immature follicles, but stimulates progesterone secretion by granulosa cells collected from large (>6 mm) mature follicles5. The present studies show that oestrogens may play an important part in regulating these divergent actions of prolactin in the ovary.
AB - Prolactin exerts well established stimulatory effects both in vitro and in vivo in the rat ovary1. However, in the ovary of higher mammals, prolactin action is not well characterised, and may differ from that observed in rodents2. For example, in human clinical conditions of physiological or pathological prolactin excess, ovarian function is depressed3, and in isolated, human granulosa cells in vitro, prolactin seems to inhibit progesterone production4. To examine direct prolactin effects in the higher mammalian ovary, we have used an in vitro porcine granulosa-cell model5. In this system, prolactin action is bipotential, depending critically on the degree of granulosa-cell differentiation attained in vivo. Prolactin suppresses steroid production by cultured granulosa cells isolated from small (1-2 mm), immature follicles, but stimulates progesterone secretion by granulosa cells collected from large (>6 mm) mature follicles5. The present studies show that oestrogens may play an important part in regulating these divergent actions of prolactin in the ovary.
UR - http://www.scopus.com/inward/record.url?scp=0018854446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018854446&partnerID=8YFLogxK
U2 - 10.1038/284262a0
DO - 10.1038/284262a0
M3 - Article
C2 - 7360258
AN - SCOPUS:0018854446
SN - 0028-0836
VL - 284
SP - 262
EP - 264
JO - Nature
JF - Nature
IS - 5753
ER -