Ocular perfusion pressure and pulsatile ocular blood flow in normal and systemic hypertensive patients

Fabio N. Kanadani, Carlos R. Figueiredo, Rafaela Morais Miranda, Patricia L.T. Cunha, Tereza Cristina M. Kanadani, Syril Dorairaj

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Purpose: Glaucomatous neuropathy can be a consequence of insufficient blood supply, increase in intraocular pressure (IOP), or other risk factors that diminish the ocular blood flow. To determine the ocular perfusion pressure (OPP) in normal and systemic hypertensive patients. Materials and methods: One hundred and twenty-one patients were enrolled in this prospective and comparative study and underwent a complete ophthalmologic examination including slit lamp examination, Goldmann applanation tonometry, stereoscopic fundus examination, and pulsatile ocular blood flow (POBF) measurements. The OPP was calculated as being the medium systemic arterial pressure (MAP) less the IOP. Only right eye values were considered for calculations using Student’s t-test. Results: The mean age of the patients was 57.5 years (36-78), and 68.5% were women. There was a statistically significant difference in the OPP of the normal and systemic hypertensive patients (p < 0.05). The difference in the OPP between these groups varied between 8.84 and 17.9 mm Hg. Conclusion: The results of this study suggest that although the systemic hypertensive patients have a higher OPP in comparison to normal patients, this increase does not mean that they also have a higher OBF (as measured by POBF tonograph). This may be caused by chronic changes in the vascular network and in the blood hemodynamics in patients with systemic hypertension.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalJournal of Current Glaucoma Practice
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Glaucoma
  • Ocular perfusion pressure
  • Pulsatile ocular blood flow

ASJC Scopus subject areas

  • Ophthalmology

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