TY - JOUR
T1 - Ocular Manifestations of Patients With Circulating Antineutrophil Cytoplasmic Antibodies
AU - Pulido, Jose S.
AU - Goeken, James A.
AU - Nerad, Jeffrey A.
AU - Sobol, Warren M.
AU - Folberg, Robert
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1990/6
Y1 - 1990/6
N2 - Antineutrophil cytoplasmic antibodies are seen in patients with systemic vasculitides, especially Wegener's granulomatosis. Antineutrophil cytoplasmic antibodies are helpful laboratory markers for these diseases. We report on the ocular findings of six patients with systemic vasculitis who had antineutrophil cytoplasmic antibodies. Four patients had systemic Wegener's granulomatosis, one had microscopic polyarteritis, and in one a specific histopathologic diagnosis could not be made. Two patients were first evaluated for systemic vasculitis because of their ocular manifestations. Ocular findings included ptosis, bilateral lacrimal gland masses, proptosis, choroidal folds, episcleritis, phlebitis, retinal and vitreous hemorrhage, keratitis sicca, and bilateral central scotomas. It was difficult to make a systemic diagnosis in all cases. If systemic vasculitis is in the differential diagnosis of a patient with suggestive ocular findings, antineutrophil cytoplasmic antibody testing should be considered. A prospective study of antineutrophil cytoplasmic antibody testing should be considered in patients with ocular findings that suggest the possibility of vasculitis.
AB - Antineutrophil cytoplasmic antibodies are seen in patients with systemic vasculitides, especially Wegener's granulomatosis. Antineutrophil cytoplasmic antibodies are helpful laboratory markers for these diseases. We report on the ocular findings of six patients with systemic vasculitis who had antineutrophil cytoplasmic antibodies. Four patients had systemic Wegener's granulomatosis, one had microscopic polyarteritis, and in one a specific histopathologic diagnosis could not be made. Two patients were first evaluated for systemic vasculitis because of their ocular manifestations. Ocular findings included ptosis, bilateral lacrimal gland masses, proptosis, choroidal folds, episcleritis, phlebitis, retinal and vitreous hemorrhage, keratitis sicca, and bilateral central scotomas. It was difficult to make a systemic diagnosis in all cases. If systemic vasculitis is in the differential diagnosis of a patient with suggestive ocular findings, antineutrophil cytoplasmic antibody testing should be considered. A prospective study of antineutrophil cytoplasmic antibody testing should be considered in patients with ocular findings that suggest the possibility of vasculitis.
UR - http://www.scopus.com/inward/record.url?scp=0025367710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025367710&partnerID=8YFLogxK
U2 - 10.1001/archopht.1990.01070080087041
DO - 10.1001/archopht.1990.01070080087041
M3 - Article
C2 - 2350286
AN - SCOPUS:0025367710
SN - 0003-9950
VL - 108
SP - 845
EP - 850
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 6
ER -