Ocular manifestations of patients with circulating antineutrophil cytoplasmic antibodies

Jose S Pulido, J. A. Goeken, J. A. Nerad, W. M. Sobol, R. Folberg

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Abstract

Antineutrophil cytoplasmic antibodies are seen in patients with systemic vasculitides, especially Wegener's granulomatosis. Antineutrophil cytoplasmic antibodies are helpful laboratory markers for these diseases. We report on the ocular findings of six patients with systemic vasculitis who had antineutrophil cytoplasmic antibodies. Four patients had systemic Wegener's granulomatosis, one had microscopic polyarteritis, and in one a specific histopathologic diagnosis could not be made. Two patients were first evaluated for systemic vasculitis because of their ocular manifestations. Ocular findings included ptosis, bilateral lacrimal gland masses, proptosis, choroidal folds, episcleritis, phlebitis, retinal and vitreous hemorrhage, keratitis sicca, and bilateral central scotomas. It was difficult to make a systemic diagnosis in all cases. If systemic vasculitis is in the differential diagnosis of a patient with suggestive ocular findings, antineutrophil cytoplasmic antibody testing should be considered. A prospective study of antineutrophil cytoplasmic antibody testing should be considered in patients with ocular findings that suggest the possibility of vasculitis.

Original languageEnglish (US)
Pages (from-to)845-850
Number of pages6
JournalArchives of Ophthalmology
Volume108
Issue number6
StatePublished - 1990
Externally publishedYes

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Eye Manifestations
Antineutrophil Cytoplasmic Antibodies
Systemic Vasculitis
Granulomatosis with Polyangiitis
Scleritis
Retinal Hemorrhage
Scotoma
Vitreous Hemorrhage
Phlebitis
Lacrimal Apparatus
Exophthalmos
Vasculitis
Differential Diagnosis
Biomarkers
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Pulido, J. S., Goeken, J. A., Nerad, J. A., Sobol, W. M., & Folberg, R. (1990). Ocular manifestations of patients with circulating antineutrophil cytoplasmic antibodies. Archives of Ophthalmology, 108(6), 845-850.

Ocular manifestations of patients with circulating antineutrophil cytoplasmic antibodies. / Pulido, Jose S; Goeken, J. A.; Nerad, J. A.; Sobol, W. M.; Folberg, R.

In: Archives of Ophthalmology, Vol. 108, No. 6, 1990, p. 845-850.

Research output: Contribution to journalArticle

Pulido, JS, Goeken, JA, Nerad, JA, Sobol, WM & Folberg, R 1990, 'Ocular manifestations of patients with circulating antineutrophil cytoplasmic antibodies', Archives of Ophthalmology, vol. 108, no. 6, pp. 845-850.
Pulido, Jose S ; Goeken, J. A. ; Nerad, J. A. ; Sobol, W. M. ; Folberg, R. / Ocular manifestations of patients with circulating antineutrophil cytoplasmic antibodies. In: Archives of Ophthalmology. 1990 ; Vol. 108, No. 6. pp. 845-850.
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