TY - JOUR
T1 - Ocular graft-versus-host disease
T2 - A review
AU - Balasubramaniam, Saranya C.
AU - Raja, Harish
AU - Nau, Cherie B.
AU - Shen, Joanne F.
AU - Schornack, Muriel M.
N1 - Publisher Copyright:
© 2015 Contact Lens Association of Ophthalmologists.
PY - 2015/9/11
Y1 - 2015/9/11
N2 - Hematopoietic stem cell transplantation is important in the management of several lymphoproliferative and bone marrow disorders. Graft-versus-host disease (GVHD) involves inflammatory manifestations that arise after transplant and can affect many organs. Ocular manifestations of GVHD are common, and eye care providers must understand this disease entity. The ocular surface is most commonly involved, but GVHD can affect all parts of the eye. Ocular GVHD can be relapsing and remitting, can decrease quality of life, and can be challenging to diagnose and adequately treat. The diagnostic criteria for and grading of ocular GVHD continue to evolve. This review aims to summarize current definitions, clinical findings, diagnostic criteria, and management of ocular GVHD. The care of patients with ocular GVHD requires a multidisciplinary approach.
AB - Hematopoietic stem cell transplantation is important in the management of several lymphoproliferative and bone marrow disorders. Graft-versus-host disease (GVHD) involves inflammatory manifestations that arise after transplant and can affect many organs. Ocular manifestations of GVHD are common, and eye care providers must understand this disease entity. The ocular surface is most commonly involved, but GVHD can affect all parts of the eye. Ocular GVHD can be relapsing and remitting, can decrease quality of life, and can be challenging to diagnose and adequately treat. The diagnostic criteria for and grading of ocular GVHD continue to evolve. This review aims to summarize current definitions, clinical findings, diagnostic criteria, and management of ocular GVHD. The care of patients with ocular GVHD requires a multidisciplinary approach.
KW - Dry eye syndrome
KW - Graft-versus-host disease
KW - Keratoconjunctivitis sicca
KW - Scleral lenses
KW - Stem cell transplant
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U2 - 10.1097/ICL.0000000000000150
DO - 10.1097/ICL.0000000000000150
M3 - Review article
C2 - 26214529
AN - SCOPUS:84941214350
SN - 1542-2321
VL - 41
SP - 256
EP - 261
JO - Eye and Contact Lens
JF - Eye and Contact Lens
IS - 5
ER -