Octreotide changes serum thyrotropin (TSH) glycoisomer distribution as assessed by lectin chromatography in a TSH macroadenoma patient

Thomas B. Francis, Robert C. Smallridge, John Kane, James A. Magner

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

A 28-yr-old woman with hyperthyroidism due to a TSH/GH-secreting macroadenoma was treated preoperatively with octreotide to attain euthyroidal status. Lectin chromatography, performed on her immunopurified serum TSH obtained at baseline and 1 week after 50 μg three times daily octreotide therapy, revealed a significant increase in ricin binding after octreotide. This result is consistent with increased amounts of TSH isoforms with more exposed galactose residues. Further clinical studies to elucidate the effects of pharmacological agents on serum TSH isoforms and TSH bioactivity are needed.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume77
Issue number1
DOIs
StatePublished - Jul 1993

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Octreotide changes serum thyrotropin (TSH) glycoisomer distribution as assessed by lectin chromatography in a TSH macroadenoma patient'. Together they form a unique fingerprint.

  • Cite this