Octreotide changes serum thyrotropin (TSH) glycoisomer distribution as assessed by lectin chromatography in a TSH macroadenoma patient

Thomas B. Francis, Robert Christian Smallridge, John Kane, James A. Magner

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A 28-yr-old woman with hyperthyroidism due to a TSH/GH-secreting macroadenoma was treated preoperatively with octreotide to attain euthyroidal status. Lectin chromatography, performed on her immunopurified serum TSH obtained at baseline and 1 week after 50 μg three times daily octreotide therapy, revealed a significant increase in ricin binding after octreotide. This result is consistent with increased amounts of TSH isoforms with more exposed galactose residues. Further clinical studies to elucidate the effects of pharmacological agents on serum TSH isoforms and TSH bioactivity are needed.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume77
Issue number1
StatePublished - Jul 1993
Externally publishedYes

Fingerprint

Octreotide
Thyrotropin
Chromatography
Lectins
Protein Isoforms
Serum
Ricin
Hyperthyroidism
Bioactivity
Galactose
Pharmacology
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Octreotide changes serum thyrotropin (TSH) glycoisomer distribution as assessed by lectin chromatography in a TSH macroadenoma patient. / Francis, Thomas B.; Smallridge, Robert Christian; Kane, John; Magner, James A.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 77, No. 1, 07.1993, p. 183-187.

Research output: Contribution to journalArticle

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