Occurrence of autoimmune diseases and relationship of autoantibody expression with HLA phenotypes in mutticase rheumatoid arthritis families

Veena D Taneja, R. R. Singh, A. N. Malaviya, C. Anand, N. K. Mehra

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Presencc of autoimmune diseases and relationship of autoantibody expression with HLA association has been studied in 44 multicase rheumatoid arthritis (RA) families of Asian Indian origin. An increased prevalence of systemic lupus erythematosus (SLE) was observed in relatives (2.3% Although HLA-DR4 segregated preferentially with seropositivity in general, no difference. was observed among seropositive versus seronegative RA. On the other hand, no HLA association was observed with ANF positivity in these families. An increased frequency of DR7 in the ANF negative and RF negative group of RA patients compared to positive groups suggests that it may act as protective element for the development of autoantibodies in RA. An increased occurrence of DR4 in relatives affected with SLE was observed, While RA segregated mostly with HLA-DK4 in these families, autoimmune thyroid disease and insulin dependent diabetes mellitus (IDDM) segregated with HLA-DR3 suggesting the involvement of at least two sets of HLA-linked autoimmunity favouring susceptibility genes in the Indian population.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalScandinavian Journal of Rheumatology
Volume22
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Autoantibodies
Autoimmune Diseases
Rheumatoid Arthritis
Phenotype
Atrial Natriuretic Factor
Systemic Lupus Erythematosus
HLA-DR3 Antigen
HLA-DR4 Antigen
Thyroid Diseases
Autoimmunity
Type 1 Diabetes Mellitus
Population
Genes

Keywords

  • Autoantibodies
  • Autoimmune diseases
  • HLA
  • Multicase families

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Occurrence of autoimmune diseases and relationship of autoantibody expression with HLA phenotypes in mutticase rheumatoid arthritis families. / Taneja, Veena D; Singh, R. R.; Malaviya, A. N.; Anand, C.; Mehra, N. K.

In: Scandinavian Journal of Rheumatology, Vol. 22, No. 4, 1993, p. 152-157.

Research output: Contribution to journalArticle

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AU - Singh, R. R.

AU - Malaviya, A. N.

AU - Anand, C.

AU - Mehra, N. K.

PY - 1993

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N2 - Presencc of autoimmune diseases and relationship of autoantibody expression with HLA association has been studied in 44 multicase rheumatoid arthritis (RA) families of Asian Indian origin. An increased prevalence of systemic lupus erythematosus (SLE) was observed in relatives (2.3% Although HLA-DR4 segregated preferentially with seropositivity in general, no difference. was observed among seropositive versus seronegative RA. On the other hand, no HLA association was observed with ANF positivity in these families. An increased frequency of DR7 in the ANF negative and RF negative group of RA patients compared to positive groups suggests that it may act as protective element for the development of autoantibodies in RA. An increased occurrence of DR4 in relatives affected with SLE was observed, While RA segregated mostly with HLA-DK4 in these families, autoimmune thyroid disease and insulin dependent diabetes mellitus (IDDM) segregated with HLA-DR3 suggesting the involvement of at least two sets of HLA-linked autoimmunity favouring susceptibility genes in the Indian population.

AB - Presencc of autoimmune diseases and relationship of autoantibody expression with HLA association has been studied in 44 multicase rheumatoid arthritis (RA) families of Asian Indian origin. An increased prevalence of systemic lupus erythematosus (SLE) was observed in relatives (2.3% Although HLA-DR4 segregated preferentially with seropositivity in general, no difference. was observed among seropositive versus seronegative RA. On the other hand, no HLA association was observed with ANF positivity in these families. An increased frequency of DR7 in the ANF negative and RF negative group of RA patients compared to positive groups suggests that it may act as protective element for the development of autoantibodies in RA. An increased occurrence of DR4 in relatives affected with SLE was observed, While RA segregated mostly with HLA-DK4 in these families, autoimmune thyroid disease and insulin dependent diabetes mellitus (IDDM) segregated with HLA-DR3 suggesting the involvement of at least two sets of HLA-linked autoimmunity favouring susceptibility genes in the Indian population.

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