Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson's disease over time

Michaela D. Gjerstad, Bradley F Boeve, T. Wentzel-Larsen, D. Aarsland, J. P. Larsen

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Objective: To examine the occurrence and clinical and demographic correlates of REM sleep behaviour disorder (RBD) in patients with Parkinson's disease (PD) in a community-based cohort over 8 years. Methods: 231 patients with PD were included in a population-based prevalence study in 1993. Patients were then followed prospectively and reexamined after 4 and 8 years. Semi-structured interviews for information on clinical and demographic data were applied at all study visits. Standardised rating scales of parkinsonism, depression and cognitive impairment were used. The diagnosis of probable RBD (pRBD) was based on a sleep questionnaire. Proportional-odds ordinal logistic regression models for clustered data were used to study the relationship between pRBD and various demographic and clinical variables. Results: 231 patients were evaluated for RBD in 1993 and, after 4 and 8 years, 142 and 89 patients, respectively, were available for re-evaluation. The frequency of pRBD varied from 14.6% to 27% during the study period. Probable RBD was related to male gender, higher dopaminergic treatment and less severe parkinsonism. Conclusion: We found that the frequency of pRBD varied over time and that it is associated with male gender, less parkinsonism and higher levodopa equivalent dose. Our findings indicate that dopaminergic therapy may contribute to the expression of RBD and that RBD is symptomatic in earlier stages of PD.

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume79
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

REM Sleep Behavior Disorder
Parkinson Disease
Parkinsonian Disorders
Demography
Logistic Models
Levodopa
Sleep
Cross-Sectional Studies
Interviews
Depression
Therapeutics
Population

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson's disease over time. / Gjerstad, Michaela D.; Boeve, Bradley F; Wentzel-Larsen, T.; Aarsland, D.; Larsen, J. P.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 79, No. 4, 04.2008, p. 387-391.

Research output: Contribution to journalArticle

@article{3f1cbf4e438a4290a2315025acdb80cd,
title = "Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson's disease over time",
abstract = "Objective: To examine the occurrence and clinical and demographic correlates of REM sleep behaviour disorder (RBD) in patients with Parkinson's disease (PD) in a community-based cohort over 8 years. Methods: 231 patients with PD were included in a population-based prevalence study in 1993. Patients were then followed prospectively and reexamined after 4 and 8 years. Semi-structured interviews for information on clinical and demographic data were applied at all study visits. Standardised rating scales of parkinsonism, depression and cognitive impairment were used. The diagnosis of probable RBD (pRBD) was based on a sleep questionnaire. Proportional-odds ordinal logistic regression models for clustered data were used to study the relationship between pRBD and various demographic and clinical variables. Results: 231 patients were evaluated for RBD in 1993 and, after 4 and 8 years, 142 and 89 patients, respectively, were available for re-evaluation. The frequency of pRBD varied from 14.6{\%} to 27{\%} during the study period. Probable RBD was related to male gender, higher dopaminergic treatment and less severe parkinsonism. Conclusion: We found that the frequency of pRBD varied over time and that it is associated with male gender, less parkinsonism and higher levodopa equivalent dose. Our findings indicate that dopaminergic therapy may contribute to the expression of RBD and that RBD is symptomatic in earlier stages of PD.",
author = "Gjerstad, {Michaela D.} and Boeve, {Bradley F} and T. Wentzel-Larsen and D. Aarsland and Larsen, {J. P.}",
year = "2008",
month = "4",
doi = "10.1136/jnnp.2007.116830",
language = "English (US)",
volume = "79",
pages = "387--391",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "4",

}

TY - JOUR

T1 - Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson's disease over time

AU - Gjerstad, Michaela D.

AU - Boeve, Bradley F

AU - Wentzel-Larsen, T.

AU - Aarsland, D.

AU - Larsen, J. P.

PY - 2008/4

Y1 - 2008/4

N2 - Objective: To examine the occurrence and clinical and demographic correlates of REM sleep behaviour disorder (RBD) in patients with Parkinson's disease (PD) in a community-based cohort over 8 years. Methods: 231 patients with PD were included in a population-based prevalence study in 1993. Patients were then followed prospectively and reexamined after 4 and 8 years. Semi-structured interviews for information on clinical and demographic data were applied at all study visits. Standardised rating scales of parkinsonism, depression and cognitive impairment were used. The diagnosis of probable RBD (pRBD) was based on a sleep questionnaire. Proportional-odds ordinal logistic regression models for clustered data were used to study the relationship between pRBD and various demographic and clinical variables. Results: 231 patients were evaluated for RBD in 1993 and, after 4 and 8 years, 142 and 89 patients, respectively, were available for re-evaluation. The frequency of pRBD varied from 14.6% to 27% during the study period. Probable RBD was related to male gender, higher dopaminergic treatment and less severe parkinsonism. Conclusion: We found that the frequency of pRBD varied over time and that it is associated with male gender, less parkinsonism and higher levodopa equivalent dose. Our findings indicate that dopaminergic therapy may contribute to the expression of RBD and that RBD is symptomatic in earlier stages of PD.

AB - Objective: To examine the occurrence and clinical and demographic correlates of REM sleep behaviour disorder (RBD) in patients with Parkinson's disease (PD) in a community-based cohort over 8 years. Methods: 231 patients with PD were included in a population-based prevalence study in 1993. Patients were then followed prospectively and reexamined after 4 and 8 years. Semi-structured interviews for information on clinical and demographic data were applied at all study visits. Standardised rating scales of parkinsonism, depression and cognitive impairment were used. The diagnosis of probable RBD (pRBD) was based on a sleep questionnaire. Proportional-odds ordinal logistic regression models for clustered data were used to study the relationship between pRBD and various demographic and clinical variables. Results: 231 patients were evaluated for RBD in 1993 and, after 4 and 8 years, 142 and 89 patients, respectively, were available for re-evaluation. The frequency of pRBD varied from 14.6% to 27% during the study period. Probable RBD was related to male gender, higher dopaminergic treatment and less severe parkinsonism. Conclusion: We found that the frequency of pRBD varied over time and that it is associated with male gender, less parkinsonism and higher levodopa equivalent dose. Our findings indicate that dopaminergic therapy may contribute to the expression of RBD and that RBD is symptomatic in earlier stages of PD.

UR - http://www.scopus.com/inward/record.url?scp=41149181286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41149181286&partnerID=8YFLogxK

U2 - 10.1136/jnnp.2007.116830

DO - 10.1136/jnnp.2007.116830

M3 - Article

VL - 79

SP - 387

EP - 391

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 4

ER -