Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies

A. B. Graves, C. M. Van Duijn, V. Chandra, L. Fratiglioni, A. Heyman, A. F. Jorm, E. Kokmen, K. Kondo, J. A. Mortimer, Walter A Rocca, S. L. Shalat, H. Soininen, A. Hofman

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Abstract

A meta-analysis, involving the secondary analysis of original data from 11 case-control studies of Alzheimer's disease, is presented for occupational exposure to solvents and lead. Three studies had data on occupational exposure to solvents. Among cases, 21.3% were reported to have been exposed; among controls, this figure was comparable (20.9%). This yielded a pooled matched relative risk of 0.76 (95% CI: 0.47-1.23). Four studies had data on exposure to lead. Exposure frequencies were 6.1% in cases and 8.3% in controls. This resulted in a pooled matched relative risk of 0.71 (95% CI: 0.36-1.41). The meta-analysis was particularly useful in validating negative results from individual studies and in increasing the statistical power for the analysis of lead exposure, where stratum-specific cell sizes were frequently smaller than five in individual studies. However, since exposure in the various studies was ascertained in a rather broad manner, prospective studies are recommended which focus on high-risk occupational populations and which determine the incidence of Alzheimer's disease in these and comparable unexposed populations.

Original languageEnglish (US)
JournalInternational Journal of Epidemiology
Volume20
Issue numberSUPPL. 2
StatePublished - 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Epidemiology

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Graves, A. B., Van Duijn, C. M., Chandra, V., Fratiglioni, L., Heyman, A., Jorm, A. F., Kokmen, E., Kondo, K., Mortimer, J. A., Rocca, W. A., Shalat, S. L., Soininen, H., & Hofman, A. (1991). Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies. International Journal of Epidemiology, 20(SUPPL. 2).