TY - JOUR
T1 - Occupational and environmental risk factors for idiopathic pulmonary fibrosis
T2 - A multicenter case-control study
AU - Baumgartner, Kathy B.
AU - Samet, Jonathan M.
AU - Coultas, David B.
AU - Stidley, Christine A.
AU - Hunt, William C.
AU - Colby, Thomas V.
AU - Waldron, James A.
AU - Baughman, Robert
AU - Davis, Gerald S.
AU - Garcia, Joe G.N.
AU - Hunningshake, Gary W.
AU - Kallay, Michael C.
AU - King, Talmadge E.
AU - Krowka, Michael J.
AU - Rennard, Stephen I.
AU - Ryu, Jay H.
AU - Sherman, Charles B.
AU - Smith, Lewis J.
AU - Toews, Galen
AU - Winterbauer, Richard H.
PY - 2000/8/15
Y1 - 2000/8/15
N2 - Occupational exposures were investigated in a multicenter case-control study of clinically and histologically diagnosed idiopathic pulmonary fibrosis (IPF), a chronic diffuse interstitial lung disease of unknown etiology. Results are based on 248 cases, aged 20-75 years, diagnosed at 16 referral centers between January 1989 and July 1993. There were 491 controls ascertained by random digit dialing and matched to cases on sex, age, and geographic region. Data were collected using a standard telephone questionnaire. Occupational factors were based on a detailed history of jobs lasting 6 months or more and job activity, hobby, and specific substance checklists. Several occupational factors, adjusted for age and smoking in conditional multivariate logistic regression analyses, were significantly associated with IPF: farming (odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.5); livestock (OR = 2.7, 95% CI: 1.3, 5.5); hairdressing (OR = 4.4, 95% CI: 1.2, 16.3); metal dust (OR = 2.0, 95% CI: 1.0, 4.0); raising birds (OR = 4.7, 95% CI: 1.6, 14.1); stone cutting/polishing (OR = 3.9, 95% CI: 1.2, 12.7); and vegetable dust/animal dust (OR = 4.7, 95% CI: 2.1, 10.4). Interaction was detected between smoking and exposure to livestock (p = 0.06) and farming (p = 0.08). Results confirm previous studies showing increased risk associated with dusty environments.
AB - Occupational exposures were investigated in a multicenter case-control study of clinically and histologically diagnosed idiopathic pulmonary fibrosis (IPF), a chronic diffuse interstitial lung disease of unknown etiology. Results are based on 248 cases, aged 20-75 years, diagnosed at 16 referral centers between January 1989 and July 1993. There were 491 controls ascertained by random digit dialing and matched to cases on sex, age, and geographic region. Data were collected using a standard telephone questionnaire. Occupational factors were based on a detailed history of jobs lasting 6 months or more and job activity, hobby, and specific substance checklists. Several occupational factors, adjusted for age and smoking in conditional multivariate logistic regression analyses, were significantly associated with IPF: farming (odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.5); livestock (OR = 2.7, 95% CI: 1.3, 5.5); hairdressing (OR = 4.4, 95% CI: 1.2, 16.3); metal dust (OR = 2.0, 95% CI: 1.0, 4.0); raising birds (OR = 4.7, 95% CI: 1.6, 14.1); stone cutting/polishing (OR = 3.9, 95% CI: 1.2, 12.7); and vegetable dust/animal dust (OR = 4.7, 95% CI: 2.1, 10.4). Interaction was detected between smoking and exposure to livestock (p = 0.06) and farming (p = 0.08). Results confirm previous studies showing increased risk associated with dusty environments.
KW - Case-control studies
KW - Environmental exposure
KW - Occupational exposure
KW - Pulmonary fibrosis
KW - Risk factors
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U2 - 10.1093/aje/152.4.307
DO - 10.1093/aje/152.4.307
M3 - Article
C2 - 10968375
AN - SCOPUS:0034663835
SN - 0002-9262
VL - 152
SP - 307
EP - 315
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 4
ER -