Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study

Joel R. Saper, David W. Dodick, Stephen D. Silberstein, Sally McCarville, Mark Sun, Peter J. Goadsby

Research output: Contribution to journalArticle

247 Scopus citations

Abstract

Background: Medically intractable chronic migraine (CM) is a disabling illness characterized by headache ≥15 days per month. Methods: A multicenter, randomized, blinded, controlled feasibility study was conducted to obtain preliminary safety and efficacy data on occipital nerve stimulation (ONS) in CM. Eligible subjects received an occipital nerve block, and responders were randomized to adjustable stimulation (AS), preset stimulation (PS) or medical management (MM) groups. Results: Seventy-five of 110 subjects were assigned to a treatment group; complete diary data were available for 66. A responder was defined as a subject who achieved a 50% or greater reduction in number of headache days per month or a three-point or greater reduction in average overall pain intensity compared with baseline. Three-month responder rates were 39% for AS, 6% for PS and 0% for MM. No unanticipated adverse device events occurred. Lead migration occurred in 12 of 51 (24%) subjects. Conclusion: The results of this feasibility study offer promise and should prompt further controlled studies of ONS in CM.

Original languageEnglish (US)
Pages (from-to)271-285
Number of pages15
JournalCephalalgia
Volume31
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • Intractable chronic migraine headache
  • chronic migraine headache
  • device implantation
  • headache days
  • occipital nerve stimulation

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study'. Together they form a unique fingerprint.

  • Cite this