TY - JOUR
T1 - Obstructive sleep apnea, inflammation, and the metabolic syndrome
AU - Calvin, Andrew D.
AU - Albuquerque, Felipe N.
AU - Lopez-Jimenez, Francisco
AU - Somers, Virend K.
PY - 2009/8/1
Y1 - 2009/8/1
N2 - The combination of metabolic syndrome and obstructive sleep apnea (OSA) has been termed "syndrome Z." The prevalence of both OSA and metabolic syndrome is increasing worldwide, in part linked to the epidemic of obesity. Beyond their epidemiologic relationship, growing evidence suggests that OSA may be causally related to metabolic syndrome. We are only beginning to understand the potential mechanisms underlying the OSA-metabolic syndrome interaction. Although there is no clear consensus, there is growing evidence that alterations in the hypothalamic-pituitary axis, generation of reactive oxygen species (ROS) due to repetitive hypoxia, inflammation, and generation of adipokines may be implicated in the changes associated with both OSA and metabolic syndrome. Whether some or all of these metabolic alterations mechanistically link OSA to metabolic syndrome remains to be proven, but it is an area of intense scientific interest.
AB - The combination of metabolic syndrome and obstructive sleep apnea (OSA) has been termed "syndrome Z." The prevalence of both OSA and metabolic syndrome is increasing worldwide, in part linked to the epidemic of obesity. Beyond their epidemiologic relationship, growing evidence suggests that OSA may be causally related to metabolic syndrome. We are only beginning to understand the potential mechanisms underlying the OSA-metabolic syndrome interaction. Although there is no clear consensus, there is growing evidence that alterations in the hypothalamic-pituitary axis, generation of reactive oxygen species (ROS) due to repetitive hypoxia, inflammation, and generation of adipokines may be implicated in the changes associated with both OSA and metabolic syndrome. Whether some or all of these metabolic alterations mechanistically link OSA to metabolic syndrome remains to be proven, but it is an area of intense scientific interest.
UR - http://www.scopus.com/inward/record.url?scp=68649118427&partnerID=8YFLogxK
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U2 - 10.1089/met.2008.0093
DO - 10.1089/met.2008.0093
M3 - Review article
C2 - 19344228
AN - SCOPUS:68649118427
SN - 1540-4196
VL - 7
SP - 271
EP - 277
JO - Metabolic Syndrome and Related Disorders
JF - Metabolic Syndrome and Related Disorders
IS - 4
ER -