Obstacles to translating genotype-phenotype correlates in metabolic disease

Anu Sharma; Adrian Vella

doi:10.1152/physiol.00009.2016

Obstacles to translating genotype-phenotype correlates in metabolic disease

Anu Sharma, Adrian Vella

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.

Original language	English (US)
Pages (from-to)	42-50
Number of pages	9
Journal	Physiology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00009.2016
State	Published - Jan 2017

ASJC Scopus subject areas

Physiology

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abstract = "Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.",

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Obstacles to translating genotype-phenotype correlates in metabolic disease

Abstract

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