Obstacles to translating genotype-phenotype correlates in metabolic disease

Anu Sharma, Adrian Vella

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future therapeutic targets. Here, we review the physiological mechanisms of diabetes-associated variants that affect glycemia.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalPhysiology
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2017

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ASJC Scopus subject areas

  • Physiology

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