Objective but Not Subjective Short Sleep Duration Is Associated With Hypertension in Obstructive Sleep Apnea

Rong Ren, Naima Covassin, Linghui Yang, Yun Li, Ye Zhang, Junying Zhou, Lu Tan, Taomei Li, Xiao Li, Yanyan Wang, Jihui Zhang, Yun Kwok Wing, Weimin Li, Virend Somers, Xiangdong Tang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Extremes of sleep duration and obstructive sleep apnea (OSA) are both associated with hypertension. We aimed to explore whether sleep duration modifies the relationship between OSA and prevalent hypertension, using both objective and subjective measures of total sleep duration. A total of 7107 OSA patients and 1118 primary snorers were included in the study. Hypertension was defined based either on direct blood pressure measures or on diagnosis by a physician. Objective sleep duration was derived by polysomnography and subjective sleep duration was self-reported. Logistic regression models were used to estimate the associations between objective/subjective sleep duration and hypertension prevalence in OSA and primary snorers. Compared with primary snorers, OSA combined with objective sleep duration of 5 to 6 hours increased the odds of hypertension by 45% (odds ratio, 1.45; 95% confidence interval, 1.14-1.84), whereas OSA combined with objective sleep duration <5 hours further increased the odds of hypertension by 80% (odds ratio, 1.80; 95% confidence interval, 1.33-2.42). These results were independent of major confounding factors frequently associated with OSA or hypertension. In stratified analysis by sleep duration, risk of hypertension in those with extremely short sleep (<5 hours) was not significantly different between OSA and primary snorers, whereas odds were significant for OSA in the other 4 sleep duration strata (5-6, 6-7, 7-8, and >8 hours). No significance was evident using subjective sleep duration. We conclude that objective short sleep duration is associated with hypertension in OSA patients. Extremely short sleep duration in itself may actually be even more detrimental than OSA in terms of hypertension risk.

Original languageEnglish (US)
Pages (from-to)610-617
Number of pages8
JournalHypertension (Dallas, Tex. : 1979)
Volume72
Issue number3
DOIs
StatePublished - Sep 1 2018

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Obstructive Sleep Apnea
Sleep
Hypertension
Logistic Models
Polysomnography
Odds Ratio
Confidence Intervals
Blood Pressure
Physicians

Keywords

  • blood pressure
  • hypertension
  • polysomnography
  • sleep
  • sleep apnea, obstructive

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Objective but Not Subjective Short Sleep Duration Is Associated With Hypertension in Obstructive Sleep Apnea. / Ren, Rong; Covassin, Naima; Yang, Linghui; Li, Yun; Zhang, Ye; Zhou, Junying; Tan, Lu; Li, Taomei; Li, Xiao; Wang, Yanyan; Zhang, Jihui; Wing, Yun Kwok; Li, Weimin; Somers, Virend; Tang, Xiangdong.

In: Hypertension (Dallas, Tex. : 1979), Vol. 72, No. 3, 01.09.2018, p. 610-617.

Research output: Contribution to journalArticle

Ren, R, Covassin, N, Yang, L, Li, Y, Zhang, Y, Zhou, J, Tan, L, Li, T, Li, X, Wang, Y, Zhang, J, Wing, YK, Li, W, Somers, V & Tang, X 2018, 'Objective but Not Subjective Short Sleep Duration Is Associated With Hypertension in Obstructive Sleep Apnea', Hypertension (Dallas, Tex. : 1979), vol. 72, no. 3, pp. 610-617. https://doi.org/10.1161/HYPERTENSIONAHA.118.11027
Ren, Rong ; Covassin, Naima ; Yang, Linghui ; Li, Yun ; Zhang, Ye ; Zhou, Junying ; Tan, Lu ; Li, Taomei ; Li, Xiao ; Wang, Yanyan ; Zhang, Jihui ; Wing, Yun Kwok ; Li, Weimin ; Somers, Virend ; Tang, Xiangdong. / Objective but Not Subjective Short Sleep Duration Is Associated With Hypertension in Obstructive Sleep Apnea. In: Hypertension (Dallas, Tex. : 1979). 2018 ; Vol. 72, No. 3. pp. 610-617.
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