Obesity-related cardiovascular disease: Implications of obstructive sleep apnea

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

Obesity and obstructive sleep apnea (OSA) often coexist. OSA has been linked to cardiovascular disease. Thus, OSA may contribute to the cardiovascular consequences of obesity. In this review, we explore clinical and pathophysiological interactions between obesity, cardiovascular disease and OSA. We discuss the mechanisms whereby OSA may contribute to hypertension, atherosclerosis, insulin resistance and atrial fibrillation associated with obesity, and emphasize the potential implications for understanding why only a subgroup of obese patients develop cardiovascular disease. Identification of the OSA-dependent and OSA-independent pathways in the cardiovascular pathophysiology of obesity may hold clinical and therapeutic promise.

Original languageEnglish (US)
Pages (from-to)250-260
Number of pages11
JournalDiabetes, Obesity and Metabolism
Volume8
Issue number3
DOIs
StatePublished - May 2006

Keywords

  • Cardiovascular disease
  • Obesity
  • Sleep apnea

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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