Obesity, mitochondrial dysfunction, and obstructive lung disease

Rituparna Chaudhuri, Michael A. Thompson, Christina Pabelick, Anurag Agrawal, Y. S. Prakash

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Obesity and obstructive lung diseases are present-day epidemics of enormous proportions. Although obesity is a metabolic disorder, derangements in metabolism are increasingly being recognized in lung disease as well. Obesity is now considered a major risk factor for lung diseases, yet individuals with asthma or chronic obstructive pulmonary disease are also predisposed to developing obesity. A complex interplay of genetic, environmental, and physiological processes contributes to increased risk for lung disease in obese patients. In the last decade, there has been increasing recognition of diverse noncanonical roles of mitochondria and mitochondrial dysregulation in disease pathogenesis. Here, we provide an overview of mitochondrial dysfunction in both obesity and lung disease, and highlight how dysfunction in one disease can influence the development or severity of the other via involvement of mitochondria.

Original languageEnglish (US)
Title of host publicationMechanisms and Manifestations of Obesity in Lung Disease
PublisherElsevier
Pages143-167
Number of pages25
ISBN (Electronic)9780128135549
ISBN (Print)9780128135532
DOIs
StatePublished - Sep 29 2018

Keywords

  • Asthma
  • Bioenergetics
  • COPD
  • Metabolic syndrome
  • Mitochondrial dysfunction
  • Obesity
  • Reactive oxygen species

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Chaudhuri, R., Thompson, M. A., Pabelick, C., Agrawal, A., & Prakash, Y. S. (2018). Obesity, mitochondrial dysfunction, and obstructive lung disease. In Mechanisms and Manifestations of Obesity in Lung Disease (pp. 143-167). Elsevier. https://doi.org/10.1016/B978-0-12-813553-2.00007-5