Abstract
Obesity is associated with lower brain volumes in cognitively normal elderly subjects, but no study has yet investigated the effects of obesity on brain structure in patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD). To determine if higher body mass index (BMI) is associated with brain volume deficits in cognitively impaired elderly subjects, we analyzed brain magnetic resonance imaging (MRI) scans of 700 MCI or AD patients from 2 different cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Cardiovascular Health Study-Cognition Study (CHS-CS). Tensor-based morphometry (TBM) was used to create 3-dimensional maps of regional tissue excess or deficits in subjects with MCI (ADNI, n = 399; CHS-CS, n = 77) and AD (ADNI, n = 188; CHS, n = 36). In both AD and MCI groups, higher body mass index was associated with brain volume deficits in frontal, temporal, parietal, and occipital lobes; the atrophic pattern was consistent in both ADNI and CHS populations. Cardiovascular risk factors, especially obesity, should be considered as influencing brain structure in those already afflicted by cognitive impairment and dementia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1326-1339 |
| Number of pages | 14 |
| Journal | Neurobiology of Aging |
| Volume | 31 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2010 |
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Keywords
- ADNI
- Alzheimer's disease
- Body mass index (BMI)
- Brain structure
- Mild cognitive impairment
- Tensor-based morphometry
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Aging
- Developmental Biology
- Geriatrics and Gerontology
Cite this
Obesity is linked with lower brain volume in 700 AD and MCI patients. / Ho, April J.; Raji, Cyrus A.; Becker, James T.; Lopez, Oscar L.; Kuller, Lewis H.; Hua, Xue; Lee, Suh; Hibar, Derrek; Dinov, Ivo D.; Stein, Jason L.; Jack, Clifford R Jr.; Weiner, Michael W.; Toga, Arthur W.; Thompson, Paul M.
In: Neurobiology of Aging, Vol. 31, No. 8, 08.2010, p. 1326-1339.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obesity is linked with lower brain volume in 700 AD and MCI patients
AU - Ho, April J.
AU - Raji, Cyrus A.
AU - Becker, James T.
AU - Lopez, Oscar L.
AU - Kuller, Lewis H.
AU - Hua, Xue
AU - Lee, Suh
AU - Hibar, Derrek
AU - Dinov, Ivo D.
AU - Stein, Jason L.
AU - Jack, Clifford R Jr.
AU - Weiner, Michael W.
AU - Toga, Arthur W.
AU - Thompson, Paul M.
PY - 2010/8
Y1 - 2010/8
N2 - Obesity is associated with lower brain volumes in cognitively normal elderly subjects, but no study has yet investigated the effects of obesity on brain structure in patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD). To determine if higher body mass index (BMI) is associated with brain volume deficits in cognitively impaired elderly subjects, we analyzed brain magnetic resonance imaging (MRI) scans of 700 MCI or AD patients from 2 different cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Cardiovascular Health Study-Cognition Study (CHS-CS). Tensor-based morphometry (TBM) was used to create 3-dimensional maps of regional tissue excess or deficits in subjects with MCI (ADNI, n = 399; CHS-CS, n = 77) and AD (ADNI, n = 188; CHS, n = 36). In both AD and MCI groups, higher body mass index was associated with brain volume deficits in frontal, temporal, parietal, and occipital lobes; the atrophic pattern was consistent in both ADNI and CHS populations. Cardiovascular risk factors, especially obesity, should be considered as influencing brain structure in those already afflicted by cognitive impairment and dementia.
AB - Obesity is associated with lower brain volumes in cognitively normal elderly subjects, but no study has yet investigated the effects of obesity on brain structure in patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD). To determine if higher body mass index (BMI) is associated with brain volume deficits in cognitively impaired elderly subjects, we analyzed brain magnetic resonance imaging (MRI) scans of 700 MCI or AD patients from 2 different cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Cardiovascular Health Study-Cognition Study (CHS-CS). Tensor-based morphometry (TBM) was used to create 3-dimensional maps of regional tissue excess or deficits in subjects with MCI (ADNI, n = 399; CHS-CS, n = 77) and AD (ADNI, n = 188; CHS, n = 36). In both AD and MCI groups, higher body mass index was associated with brain volume deficits in frontal, temporal, parietal, and occipital lobes; the atrophic pattern was consistent in both ADNI and CHS populations. Cardiovascular risk factors, especially obesity, should be considered as influencing brain structure in those already afflicted by cognitive impairment and dementia.
KW - ADNI
KW - Alzheimer's disease
KW - Body mass index (BMI)
KW - Brain structure
KW - Mild cognitive impairment
KW - Tensor-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=77954030767&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954030767&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2010.04.006
DO - 10.1016/j.neurobiolaging.2010.04.006
M3 - Article
VL - 31
SP - 1326
EP - 1339
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 8
ER -