Obesity adversely affects survival in pancreatic cancer patients

Robert R Mc Williams, Martha E. Matsumoto, Patrick A. Burch, George P. Kim, Thorvardur R. Halfdanarson, Mariza De Andrade, Kaye Reid-Lombardo, William R. Bamlet

Research output: Contribution to journalArticle

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Abstract

Background: Higher body-mass index (BMI) has been implicated as a risk factor for developing pancreatic cancer, but its effect on survival has not been thoroughly investigated. The authors assessed the association of BMI with survival in a sample of pancreatic cancer patients and used epidemiologic and clinical information to understand the contribution of diabetes and hyperglycemia. Methods: A survival analysis using Cox proportional hazards by usual adult BMI was performed on 1861 unselected patients with pancreatic adenocarcinoma; analyses were adjusted for covariates that included clinical stage, age, and sex. Secondary analyses incorporated self-reported diabetes and fasting blood glucose in the survival model. RESULTS: BMI as a continuous variable was inversely associated with survival from pancreatic adenocarcinoma (hazard ratio [HR], 1.019 for each increased unit of BMI [kg/m2], P <.001) after adjustment for age, stage, and sex. In analysis by National Institutes of Health BMI category, BMIs of 30 to 34.99 kg/m2 (HR, 1.14; 95% confidence interval [CI], 0.98-1.33), 35 to 39.99 kg/m2 (HR 1.32, 95% CI 1.08-1.62), and ≥40 (HR 1.60, 95% CI 1.26-2.04) were associated with decreased survival compared with normal BMI of 18.5 to 24.99 kg/m 2 (overall trend test P <.001). Fasting blood glucose and diabetes did not affect the results. CONCLUSIONS: Higher BMI is associated with decreased survival in pancreatic cancer. Although the mechanism of this association remains undetermined, diabetes and hyperglycemia do not appear to account for the observed association.

Original languageEnglish (US)
Pages (from-to)5054-5062
Number of pages9
JournalCancer
Volume116
Issue number21
DOIs
StatePublished - Nov 1 2010

Fingerprint

Pancreatic Neoplasms
Body Mass Index
Obesity
Survival
Confidence Intervals
Hyperglycemia
Blood Glucose
Fasting
Adenocarcinoma
National Institutes of Health (U.S.)
Survival Analysis

Keywords

  • Diabetes
  • Hyperglycemia
  • Obesity
  • Pancreatic neoplasms
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mc Williams, R. R., Matsumoto, M. E., Burch, P. A., Kim, G. P., Halfdanarson, T. R., De Andrade, M., ... Bamlet, W. R. (2010). Obesity adversely affects survival in pancreatic cancer patients. Cancer, 116(21), 5054-5062. https://doi.org/10.1002/cncr.25465

Obesity adversely affects survival in pancreatic cancer patients. / Mc Williams, Robert R; Matsumoto, Martha E.; Burch, Patrick A.; Kim, George P.; Halfdanarson, Thorvardur R.; De Andrade, Mariza; Reid-Lombardo, Kaye; Bamlet, William R.

In: Cancer, Vol. 116, No. 21, 01.11.2010, p. 5054-5062.

Research output: Contribution to journalArticle

Mc Williams, RR, Matsumoto, ME, Burch, PA, Kim, GP, Halfdanarson, TR, De Andrade, M, Reid-Lombardo, K & Bamlet, WR 2010, 'Obesity adversely affects survival in pancreatic cancer patients', Cancer, vol. 116, no. 21, pp. 5054-5062. https://doi.org/10.1002/cncr.25465
Mc Williams RR, Matsumoto ME, Burch PA, Kim GP, Halfdanarson TR, De Andrade M et al. Obesity adversely affects survival in pancreatic cancer patients. Cancer. 2010 Nov 1;116(21):5054-5062. https://doi.org/10.1002/cncr.25465
Mc Williams, Robert R ; Matsumoto, Martha E. ; Burch, Patrick A. ; Kim, George P. ; Halfdanarson, Thorvardur R. ; De Andrade, Mariza ; Reid-Lombardo, Kaye ; Bamlet, William R. / Obesity adversely affects survival in pancreatic cancer patients. In: Cancer. 2010 ; Vol. 116, No. 21. pp. 5054-5062.
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AU - De Andrade, Mariza

AU - Reid-Lombardo, Kaye

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