OAE

The Ontology of Adverse Events

Yongqun He, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao, Barry Smith

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: A medical intervention is a medical procedure or application intended to relieve or prevent illness or injury. Examples of medical interventions include vaccination and drug administration. After a medical intervention, adverse events (AEs) may occur which lie outside the intended consequences of the intervention. The representation and analysis of AEs are critical to the improvement of public health. Description: The Ontology of Adverse Events (OAE), previously named Adverse Event Ontology (AEO), is a community-driven ontology developed to standardize and integrate data relating to AEs arising subsequent to medical interventions, as well as to support computer-assisted reasoning. OAE has over 3,000 terms with unique identifiers, including terms imported from existing ontologies and more than 1,800 OAE-specific terms. In OAE, the term 'adverse event' denotes a pathological bodily process in a patient that occurs after a medical intervention. Causal adverse events are defined by OAE as those events that are causal consequences of a medical intervention. OAE represents various adverse events based on patient anatomic regions and clinical outcomes, including symptoms, signs, and abnormal processes. OAE has been used in the analysis of several different sorts of vaccine and drug adverse event data. For example, using the data extracted from the Vaccine Adverse Event Reporting System (VAERS), OAE was used to analyse vaccine adverse events associated with the administrations of different types of influenza vaccines. OAE has also been used to represent and classify the vaccine adverse events cited in package inserts of FDA-licensed human vaccines in the USA. Conclusion: OAE is a biomedical ontology that logically defines and classifies various adverse events occurring after medical interventions. OAE has successfully been applied in several adverse event studies. The OAE ontological framework provides a platform for systematic representation and analysis of adverse events and of the factors (e.g., vaccinee age) important for determining their clinical outcomes.

Original languageEnglish (US)
Article number29
JournalJournal of Biomedical Semantics
Volume5
Issue number1
DOIs
StatePublished - Jul 5 2014
Externally publishedYes

Fingerprint

Ontology
Vaccines
Biological Ontologies
Product Labeling
Influenza Vaccines
Artificial Intelligence
Pathologic Processes
Drug-Related Side Effects and Adverse Reactions
Signs and Symptoms
Vaccination
Public Health
Wounds and Injuries
Pharmaceutical Preparations
Public health

Keywords

  • Adverse event
  • Design pattern
  • Drug
  • Drug adverse event
  • OAE
  • Ontology
  • Ontology of adverse events
  • Vaccine
  • Vaccine adverse event
  • VAERS

ASJC Scopus subject areas

  • Information Systems
  • Computer Science Applications
  • Computer Networks and Communications
  • Health Informatics

Cite this

He, Y., Sarntivijai, S., Lin, Y., Xiang, Z., Guo, A., Zhang, S., ... Smith, B. (2014). OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics, 5(1), [29]. https://doi.org/10.1186/2041-1480-5-29

OAE : The Ontology of Adverse Events. / He, Yongqun; Sarntivijai, Sirarat; Lin, Yu; Xiang, Zuoshuang; Guo, Abra; Zhang, Shelley; Jagannathan, Desikan; Toldo, Luca; Tao, Cui; Smith, Barry.

In: Journal of Biomedical Semantics, Vol. 5, No. 1, 29, 05.07.2014.

Research output: Contribution to journalArticle

He, Y, Sarntivijai, S, Lin, Y, Xiang, Z, Guo, A, Zhang, S, Jagannathan, D, Toldo, L, Tao, C & Smith, B 2014, 'OAE: The Ontology of Adverse Events', Journal of Biomedical Semantics, vol. 5, no. 1, 29. https://doi.org/10.1186/2041-1480-5-29
He Y, Sarntivijai S, Lin Y, Xiang Z, Guo A, Zhang S et al. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014 Jul 5;5(1). 29. https://doi.org/10.1186/2041-1480-5-29
He, Yongqun ; Sarntivijai, Sirarat ; Lin, Yu ; Xiang, Zuoshuang ; Guo, Abra ; Zhang, Shelley ; Jagannathan, Desikan ; Toldo, Luca ; Tao, Cui ; Smith, Barry. / OAE : The Ontology of Adverse Events. In: Journal of Biomedical Semantics. 2014 ; Vol. 5, No. 1.
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