Nystatin induces secretion of interleukin (IL)-1β, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism

Raymund R. Razonable, Martin Henault, Harold L. Watson, Carlos V. Paya

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Nystatin is an antifungal compound with potent proinflammatory properties. Herein, we demonstrate that nystatin induces interleukin (IL)-1β, IL-8, and tumor necrosis factor alpha secretion through its activation of toll-like receptor 1 (TLR1) and TLR2. Hence, a TLR-dependent mechanism could serve as the molecular basis for the proinflammatory properties of nystatin.

Original languageEnglish (US)
Pages (from-to)3546-3549
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number8
DOIs
StatePublished - Aug 1 2005

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this