Nystatin induces secretion of interleukin (IL)-1β, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism

Raymund R Razonable, Martin Henault, Harold L. Watson, Carlos V. Paya

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Nystatin is an antifungal compound with potent proinflammatory properties. Herein, we demonstrate that nystatin induces interleukin (IL)-1β, IL-8, and tumor necrosis factor alpha secretion through its activation of toll-like receptor 1 (TLR1) and TLR2. Hence, a TLR-dependent mechanism could serve as the molecular basis for the proinflammatory properties of nystatin.

Original languageEnglish (US)
Pages (from-to)3546-3549
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number8
DOIs
StatePublished - Aug 2005

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Nystatin
Toll-Like Receptors
Interleukin-8
Interleukin-1
Tumor Necrosis Factor-alpha
Toll-Like Receptor 1

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Nystatin induces secretion of interleukin (IL)-1β, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism. / Razonable, Raymund R; Henault, Martin; Watson, Harold L.; Paya, Carlos V.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 8, 08.2005, p. 3546-3549.

Research output: Contribution to journalArticle

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