Nutritional support and therapy in pancreatic surgery: A position paper of the International Study Group on Pancreatic Surgery (ISGPS)

Luca Gianotti, Marc G. Besselink, Marta Sandini, Thilo Hackert, Kevin Conlon, Arja Gerritsen, Oonagh Griffin, Abe Fingerhut, Pascal Probst, Mohamed Abu Hilal, Giovanni Marchegiani, Gennaro Nappo, Alessandro Zerbi, Antonio Amodio, Julie Perinel, Mustapha Adham, Massimo Raimondo, Horacio J. Asbun, Asahi Sato, Kyoichi TakaoriShailesh V. Shrikhande, Marco Del Chiaro, Maximilian Bockhorn, Jakob R. Izbicki, Christos Dervenis, Richard M. Charnley, Marc E. Martignoni, Helmut Friess, Nicolò de Pretis, Dejan Radenkovic, Marco Montorsi, Michael G. Sarr, Charles M. Vollmer, Luca Frulloni, Markus W. Büchler, Claudio Bassi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: The optimal nutritional therapy in the field of pancreatic surgery is still debated. Methods: An international panel of recognized pancreatic surgeons and pancreatologists decided that the topic of nutritional support was of importance in pancreatic surgery. Thus, they reviewed the best contemporary literature and worked to develop a position paper to provide evidence supporting the integration of appropriate nutritional support into the overall management of patients undergoing pancreatic resection. Strength of recommendation and quality of evidence were based on the approach of the grading of recommendations assessment, development and evaluation Working Group. Results: The measurement of nutritional status should be part of routine preoperative assessment because malnutrition is a recognized risk factor for surgery-related complications. In addition to patient's weight loss and body mass index, measurement of sarcopenia and sarcopenic obesity should be considered in the preoperative evaluation because they are strong predictors of poor short-term and long-term outcomes. The available data do not show any definitive nutritional advantages for one specific type of gastrointestinal reconstruction technique after pancreatoduodenectomy over the others. Postoperative early resumption of oral intake is safe and should be encouraged within enhanced recovery protocols, but in the case of severe postoperative complications or poor tolerance of oral food after the operation, supplementary artificial nutrition should be started at once. At present, there is not enough evidence to show the benefit of avoiding oral intake in clinically stable patients who are complicated by a clinically irrelevant postoperative pancreatic fistula (a so-called biochemical leak), while special caution should be given to feeding patients with clinically relevant postoperative pancreatic fistula orally. When an artificial nutritional support is needed, enteral nutrition is preferred whenever possible over parenteral nutrition. After the operation, regardless of the type of pancreatic resection or technique of reconstruction, patients should be monitored carefully to assess for the presence of endocrine and exocrine pancreatic insufficiency. Although fecal elastase-1 is the most readily available clinical test for detection of pancreatic exocrine insufficiency, its sensitivity and specificity are low. Pancreatic enzyme replacement therapy should be initiated routinely after pancreatoduodenectomy and in patients with locally advanced disease and continued for at least 6 months after surgery, because untreated pancreatic exocrine insufficiency may result in severe nutritional derangement. Conclusion: The importance of this position paper is the consensus reached on the topic. Concentrating on nutritional support and therapy is of utmost value in pancreatic surgery for both short- and long-term outcomes.

Original languageEnglish (US)
Pages (from-to)1035-1048
Number of pages14
JournalSurgery (United States)
Volume164
Issue number5
DOIs
StatePublished - Nov 1 2018

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Nutritional Support
Exocrine Pancreatic Insufficiency
Pancreatic Fistula
Pancreaticoduodenectomy
Therapeutics
Sarcopenia
Enzyme Replacement Therapy
Literature
Pancreatic Elastase
Parenteral Nutrition
Enteral Nutrition
Nutritional Status
Malnutrition
Weight Loss
Body Mass Index
Obesity
Sensitivity and Specificity
Food

ASJC Scopus subject areas

  • Surgery

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Nutritional support and therapy in pancreatic surgery : A position paper of the International Study Group on Pancreatic Surgery (ISGPS). / Gianotti, Luca; Besselink, Marc G.; Sandini, Marta; Hackert, Thilo; Conlon, Kevin; Gerritsen, Arja; Griffin, Oonagh; Fingerhut, Abe; Probst, Pascal; Hilal, Mohamed Abu; Marchegiani, Giovanni; Nappo, Gennaro; Zerbi, Alessandro; Amodio, Antonio; Perinel, Julie; Adham, Mustapha; Raimondo, Massimo; Asbun, Horacio J.; Sato, Asahi; Takaori, Kyoichi; Shrikhande, Shailesh V.; Del Chiaro, Marco; Bockhorn, Maximilian; Izbicki, Jakob R.; Dervenis, Christos; Charnley, Richard M.; Martignoni, Marc E.; Friess, Helmut; de Pretis, Nicolò; Radenkovic, Dejan; Montorsi, Marco; Sarr, Michael G.; Vollmer, Charles M.; Frulloni, Luca; Büchler, Markus W.; Bassi, Claudio.

In: Surgery (United States), Vol. 164, No. 5, 01.11.2018, p. 1035-1048.

Research output: Contribution to journalArticle

Gianotti, L, Besselink, MG, Sandini, M, Hackert, T, Conlon, K, Gerritsen, A, Griffin, O, Fingerhut, A, Probst, P, Hilal, MA, Marchegiani, G, Nappo, G, Zerbi, A, Amodio, A, Perinel, J, Adham, M, Raimondo, M, Asbun, HJ, Sato, A, Takaori, K, Shrikhande, SV, Del Chiaro, M, Bockhorn, M, Izbicki, JR, Dervenis, C, Charnley, RM, Martignoni, ME, Friess, H, de Pretis, N, Radenkovic, D, Montorsi, M, Sarr, MG, Vollmer, CM, Frulloni, L, Büchler, MW & Bassi, C 2018, 'Nutritional support and therapy in pancreatic surgery: A position paper of the International Study Group on Pancreatic Surgery (ISGPS)', Surgery (United States), vol. 164, no. 5, pp. 1035-1048. https://doi.org/10.1016/j.surg.2018.05.040
Gianotti, Luca ; Besselink, Marc G. ; Sandini, Marta ; Hackert, Thilo ; Conlon, Kevin ; Gerritsen, Arja ; Griffin, Oonagh ; Fingerhut, Abe ; Probst, Pascal ; Hilal, Mohamed Abu ; Marchegiani, Giovanni ; Nappo, Gennaro ; Zerbi, Alessandro ; Amodio, Antonio ; Perinel, Julie ; Adham, Mustapha ; Raimondo, Massimo ; Asbun, Horacio J. ; Sato, Asahi ; Takaori, Kyoichi ; Shrikhande, Shailesh V. ; Del Chiaro, Marco ; Bockhorn, Maximilian ; Izbicki, Jakob R. ; Dervenis, Christos ; Charnley, Richard M. ; Martignoni, Marc E. ; Friess, Helmut ; de Pretis, Nicolò ; Radenkovic, Dejan ; Montorsi, Marco ; Sarr, Michael G. ; Vollmer, Charles M. ; Frulloni, Luca ; Büchler, Markus W. ; Bassi, Claudio. / Nutritional support and therapy in pancreatic surgery : A position paper of the International Study Group on Pancreatic Surgery (ISGPS). In: Surgery (United States). 2018 ; Vol. 164, No. 5. pp. 1035-1048.
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abstract = "Background: The optimal nutritional therapy in the field of pancreatic surgery is still debated. Methods: An international panel of recognized pancreatic surgeons and pancreatologists decided that the topic of nutritional support was of importance in pancreatic surgery. Thus, they reviewed the best contemporary literature and worked to develop a position paper to provide evidence supporting the integration of appropriate nutritional support into the overall management of patients undergoing pancreatic resection. Strength of recommendation and quality of evidence were based on the approach of the grading of recommendations assessment, development and evaluation Working Group. Results: The measurement of nutritional status should be part of routine preoperative assessment because malnutrition is a recognized risk factor for surgery-related complications. In addition to patient's weight loss and body mass index, measurement of sarcopenia and sarcopenic obesity should be considered in the preoperative evaluation because they are strong predictors of poor short-term and long-term outcomes. The available data do not show any definitive nutritional advantages for one specific type of gastrointestinal reconstruction technique after pancreatoduodenectomy over the others. Postoperative early resumption of oral intake is safe and should be encouraged within enhanced recovery protocols, but in the case of severe postoperative complications or poor tolerance of oral food after the operation, supplementary artificial nutrition should be started at once. At present, there is not enough evidence to show the benefit of avoiding oral intake in clinically stable patients who are complicated by a clinically irrelevant postoperative pancreatic fistula (a so-called biochemical leak), while special caution should be given to feeding patients with clinically relevant postoperative pancreatic fistula orally. When an artificial nutritional support is needed, enteral nutrition is preferred whenever possible over parenteral nutrition. After the operation, regardless of the type of pancreatic resection or technique of reconstruction, patients should be monitored carefully to assess for the presence of endocrine and exocrine pancreatic insufficiency. Although fecal elastase-1 is the most readily available clinical test for detection of pancreatic exocrine insufficiency, its sensitivity and specificity are low. Pancreatic enzyme replacement therapy should be initiated routinely after pancreatoduodenectomy and in patients with locally advanced disease and continued for at least 6 months after surgery, because untreated pancreatic exocrine insufficiency may result in severe nutritional derangement. Conclusion: The importance of this position paper is the consensus reached on the topic. Concentrating on nutritional support and therapy is of utmost value in pancreatic surgery for both short- and long-term outcomes.",
author = "Luca Gianotti and Besselink, {Marc G.} and Marta Sandini and Thilo Hackert and Kevin Conlon and Arja Gerritsen and Oonagh Griffin and Abe Fingerhut and Pascal Probst and Hilal, {Mohamed Abu} and Giovanni Marchegiani and Gennaro Nappo and Alessandro Zerbi and Antonio Amodio and Julie Perinel and Mustapha Adham and Massimo Raimondo and Asbun, {Horacio J.} and Asahi Sato and Kyoichi Takaori and Shrikhande, {Shailesh V.} and {Del Chiaro}, Marco and Maximilian Bockhorn and Izbicki, {Jakob R.} and Christos Dervenis and Charnley, {Richard M.} and Martignoni, {Marc E.} and Helmut Friess and {de Pretis}, Nicol{\`o} and Dejan Radenkovic and Marco Montorsi and Sarr, {Michael G.} and Vollmer, {Charles M.} and Luca Frulloni and B{\"u}chler, {Markus W.} and Claudio Bassi",
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TY - JOUR

T1 - Nutritional support and therapy in pancreatic surgery

T2 - A position paper of the International Study Group on Pancreatic Surgery (ISGPS)

AU - Gianotti, Luca

AU - Besselink, Marc G.

AU - Sandini, Marta

AU - Hackert, Thilo

AU - Conlon, Kevin

AU - Gerritsen, Arja

AU - Griffin, Oonagh

AU - Fingerhut, Abe

AU - Probst, Pascal

AU - Hilal, Mohamed Abu

AU - Marchegiani, Giovanni

AU - Nappo, Gennaro

AU - Zerbi, Alessandro

AU - Amodio, Antonio

AU - Perinel, Julie

AU - Adham, Mustapha

AU - Raimondo, Massimo

AU - Asbun, Horacio J.

AU - Sato, Asahi

AU - Takaori, Kyoichi

AU - Shrikhande, Shailesh V.

AU - Del Chiaro, Marco

AU - Bockhorn, Maximilian

AU - Izbicki, Jakob R.

AU - Dervenis, Christos

AU - Charnley, Richard M.

AU - Martignoni, Marc E.

AU - Friess, Helmut

AU - de Pretis, Nicolò

AU - Radenkovic, Dejan

AU - Montorsi, Marco

AU - Sarr, Michael G.

AU - Vollmer, Charles M.

AU - Frulloni, Luca

AU - Büchler, Markus W.

AU - Bassi, Claudio

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: The optimal nutritional therapy in the field of pancreatic surgery is still debated. Methods: An international panel of recognized pancreatic surgeons and pancreatologists decided that the topic of nutritional support was of importance in pancreatic surgery. Thus, they reviewed the best contemporary literature and worked to develop a position paper to provide evidence supporting the integration of appropriate nutritional support into the overall management of patients undergoing pancreatic resection. Strength of recommendation and quality of evidence were based on the approach of the grading of recommendations assessment, development and evaluation Working Group. Results: The measurement of nutritional status should be part of routine preoperative assessment because malnutrition is a recognized risk factor for surgery-related complications. In addition to patient's weight loss and body mass index, measurement of sarcopenia and sarcopenic obesity should be considered in the preoperative evaluation because they are strong predictors of poor short-term and long-term outcomes. The available data do not show any definitive nutritional advantages for one specific type of gastrointestinal reconstruction technique after pancreatoduodenectomy over the others. Postoperative early resumption of oral intake is safe and should be encouraged within enhanced recovery protocols, but in the case of severe postoperative complications or poor tolerance of oral food after the operation, supplementary artificial nutrition should be started at once. At present, there is not enough evidence to show the benefit of avoiding oral intake in clinically stable patients who are complicated by a clinically irrelevant postoperative pancreatic fistula (a so-called biochemical leak), while special caution should be given to feeding patients with clinically relevant postoperative pancreatic fistula orally. When an artificial nutritional support is needed, enteral nutrition is preferred whenever possible over parenteral nutrition. After the operation, regardless of the type of pancreatic resection or technique of reconstruction, patients should be monitored carefully to assess for the presence of endocrine and exocrine pancreatic insufficiency. Although fecal elastase-1 is the most readily available clinical test for detection of pancreatic exocrine insufficiency, its sensitivity and specificity are low. Pancreatic enzyme replacement therapy should be initiated routinely after pancreatoduodenectomy and in patients with locally advanced disease and continued for at least 6 months after surgery, because untreated pancreatic exocrine insufficiency may result in severe nutritional derangement. Conclusion: The importance of this position paper is the consensus reached on the topic. Concentrating on nutritional support and therapy is of utmost value in pancreatic surgery for both short- and long-term outcomes.

AB - Background: The optimal nutritional therapy in the field of pancreatic surgery is still debated. Methods: An international panel of recognized pancreatic surgeons and pancreatologists decided that the topic of nutritional support was of importance in pancreatic surgery. Thus, they reviewed the best contemporary literature and worked to develop a position paper to provide evidence supporting the integration of appropriate nutritional support into the overall management of patients undergoing pancreatic resection. Strength of recommendation and quality of evidence were based on the approach of the grading of recommendations assessment, development and evaluation Working Group. Results: The measurement of nutritional status should be part of routine preoperative assessment because malnutrition is a recognized risk factor for surgery-related complications. In addition to patient's weight loss and body mass index, measurement of sarcopenia and sarcopenic obesity should be considered in the preoperative evaluation because they are strong predictors of poor short-term and long-term outcomes. The available data do not show any definitive nutritional advantages for one specific type of gastrointestinal reconstruction technique after pancreatoduodenectomy over the others. Postoperative early resumption of oral intake is safe and should be encouraged within enhanced recovery protocols, but in the case of severe postoperative complications or poor tolerance of oral food after the operation, supplementary artificial nutrition should be started at once. At present, there is not enough evidence to show the benefit of avoiding oral intake in clinically stable patients who are complicated by a clinically irrelevant postoperative pancreatic fistula (a so-called biochemical leak), while special caution should be given to feeding patients with clinically relevant postoperative pancreatic fistula orally. When an artificial nutritional support is needed, enteral nutrition is preferred whenever possible over parenteral nutrition. After the operation, regardless of the type of pancreatic resection or technique of reconstruction, patients should be monitored carefully to assess for the presence of endocrine and exocrine pancreatic insufficiency. Although fecal elastase-1 is the most readily available clinical test for detection of pancreatic exocrine insufficiency, its sensitivity and specificity are low. Pancreatic enzyme replacement therapy should be initiated routinely after pancreatoduodenectomy and in patients with locally advanced disease and continued for at least 6 months after surgery, because untreated pancreatic exocrine insufficiency may result in severe nutritional derangement. Conclusion: The importance of this position paper is the consensus reached on the topic. Concentrating on nutritional support and therapy is of utmost value in pancreatic surgery for both short- and long-term outcomes.

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