NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells

Tewfik Hamidi, Carla E. Cano, Daniel Grasso, Maria Noé Garcia, Maria José Sandi, Ezequiel L. Calvo, Jean Charles Dagorn, Gwen Lomberk, Sandro Goruppi, Raul Urrutia, Arkaitz Carracedo, Guillermo Velasco, Juan L. Iovanna

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The incidence of pancreatic adenocarcinoma is increasing with more than 43,000 predicted new cases in the US and 65,000 in Europe this year. Pancreatic cancer patients have a short life expectancy with less than 3-4% 5-y survival, which results in an equivalent incidence and mortality rate. One of the major challenges in pancreatic cancer is the identification of pharmacological approaches that overcome the resistance of this cancer to therapy. Intensive research in the past decades has led to the classification of pancreatic cancers and the identification of the driver key genetic events. Despite the advances in understanding the molecular mechanisms responsible for pancreatic cancer pathogenesis, this knowledge had little impact on significantly improving the treatment for this dismal disease. In particular, we know today that the lack of therapeutic response in pancreatic cancer is due to the intrinsic high resistance of these tumors to chemotherapy and radiation, rather than to the inappropriate design of these therapeutic approaches. Thus, in order to ensure a better outcome for pancreatic cancer patients, there is a strong need for research focused on the mechanism that determines this resistant phenotype and the means that might drive enhanced response to therapy.

Original languageEnglish (US)
Pages (from-to)95-97
Number of pages3
JournalAutophagy
Volume9
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • AURKA
  • Cannabinoids
  • Glucose starvation
  • Hypoxia
  • NUPR1
  • Pancreas cancer

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Hamidi, T., Cano, C. E., Grasso, D., Garcia, M. N., Sandi, M. J., Calvo, E. L., Dagorn, J. C., Lomberk, G., Goruppi, S., Urrutia, R., Carracedo, A., Velasco, G., & Iovanna, J. L. (2013). NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells. Autophagy, 9(1), 95-97. https://doi.org/10.4161/auto.22258