Number of lymph nodes harvested from a mediastinal lymphadenectomy

Results of the randomized, prospective American College of Surgeons Oncology Group Z0030 trial

Gail E. Darling, Mark S. Allen, Paul A. Decker, Karla Ballman, Richard A. Malthaner, Richard I. Inculet, David R. Jones, Robert J. McKenna, Rodney J. Landreneau, Joe B. Putnam

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Background: Lymph node status is a major determinant of stage and survival in patients with lung cancer; however, little information is available about the expected yield of a mediastinal lymphadenectomy. Methods: The American College of Surgeons Oncology Group Z0030 prospective, randomized trial of mediastinal lymph node sampling vs complete mediastinal lymphadenectomy during pulmonary resection enrolled 1,111 patients from July 1999 to February 2004. Data from 524 patients who underwent complete mediastinal lymph node dissection were analyzed to determine the number of lymph nodes obtained. Results: The median number of additional lymph nodes harvested from a mediastinal lymphadenectomy following systematic sampling was 18 with a range of one to 72 for right-sided tumors, and 18 with a range of four to 69 for left-sided tumors. The median number of N2 nodes harvested was 11 on the right and 12 on the left. A median of at least six nodes was harvested from at least three stations in 99% of patients, and 90% of patients had at least 10 nodes harvested from three stations. Overall, 21 patients (4%) were found to have occult N2 disease. Conclusions: Although high variability exists in the actual number of lymph nodes obtained from various nodal stations, complete mediastinal lymphadenectomy removes one or more lymph nodes from all mediastinal stations. Adequate mediastinal lymphadenectomy should include stations 2R, 4R, 7, 8, and 9 for right-sided cancers and stations 4L, 5, 6, 7, 8, and 9 for left-sided cancers. Six or more nodes were resected in 99% of patients in this study. Trial registry: ClinicalTrials.gov; No.: NCT00003831; URL: clinicaltrials.gov.

Original languageEnglish (US)
Pages (from-to)1124-1129
Number of pages6
JournalChest
Volume139
Issue number5
DOIs
StatePublished - May 1 2011

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Lymph Node Excision
Lymph Nodes
Neoplasms
Registries
Lung Neoplasms
Lung
Survival

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Darling, G. E., Allen, M. S., Decker, P. A., Ballman, K., Malthaner, R. A., Inculet, R. I., ... Putnam, J. B. (2011). Number of lymph nodes harvested from a mediastinal lymphadenectomy: Results of the randomized, prospective American College of Surgeons Oncology Group Z0030 trial. Chest, 139(5), 1124-1129. https://doi.org/10.1378/chest.10-0859

Number of lymph nodes harvested from a mediastinal lymphadenectomy : Results of the randomized, prospective American College of Surgeons Oncology Group Z0030 trial. / Darling, Gail E.; Allen, Mark S.; Decker, Paul A.; Ballman, Karla; Malthaner, Richard A.; Inculet, Richard I.; Jones, David R.; McKenna, Robert J.; Landreneau, Rodney J.; Putnam, Joe B.

In: Chest, Vol. 139, No. 5, 01.05.2011, p. 1124-1129.

Research output: Contribution to journalArticle

Darling, GE, Allen, MS, Decker, PA, Ballman, K, Malthaner, RA, Inculet, RI, Jones, DR, McKenna, RJ, Landreneau, RJ & Putnam, JB 2011, 'Number of lymph nodes harvested from a mediastinal lymphadenectomy: Results of the randomized, prospective American College of Surgeons Oncology Group Z0030 trial', Chest, vol. 139, no. 5, pp. 1124-1129. https://doi.org/10.1378/chest.10-0859
Darling, Gail E. ; Allen, Mark S. ; Decker, Paul A. ; Ballman, Karla ; Malthaner, Richard A. ; Inculet, Richard I. ; Jones, David R. ; McKenna, Robert J. ; Landreneau, Rodney J. ; Putnam, Joe B. / Number of lymph nodes harvested from a mediastinal lymphadenectomy : Results of the randomized, prospective American College of Surgeons Oncology Group Z0030 trial. In: Chest. 2011 ; Vol. 139, No. 5. pp. 1124-1129.
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abstract = "Background: Lymph node status is a major determinant of stage and survival in patients with lung cancer; however, little information is available about the expected yield of a mediastinal lymphadenectomy. Methods: The American College of Surgeons Oncology Group Z0030 prospective, randomized trial of mediastinal lymph node sampling vs complete mediastinal lymphadenectomy during pulmonary resection enrolled 1,111 patients from July 1999 to February 2004. Data from 524 patients who underwent complete mediastinal lymph node dissection were analyzed to determine the number of lymph nodes obtained. Results: The median number of additional lymph nodes harvested from a mediastinal lymphadenectomy following systematic sampling was 18 with a range of one to 72 for right-sided tumors, and 18 with a range of four to 69 for left-sided tumors. The median number of N2 nodes harvested was 11 on the right and 12 on the left. A median of at least six nodes was harvested from at least three stations in 99{\%} of patients, and 90{\%} of patients had at least 10 nodes harvested from three stations. Overall, 21 patients (4{\%}) were found to have occult N2 disease. Conclusions: Although high variability exists in the actual number of lymph nodes obtained from various nodal stations, complete mediastinal lymphadenectomy removes one or more lymph nodes from all mediastinal stations. Adequate mediastinal lymphadenectomy should include stations 2R, 4R, 7, 8, and 9 for right-sided cancers and stations 4L, 5, 6, 7, 8, and 9 for left-sided cancers. Six or more nodes were resected in 99{\%} of patients in this study. Trial registry: ClinicalTrials.gov; No.: NCT00003831; URL: clinicaltrials.gov.",
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AU - Malthaner, Richard A.

AU - Inculet, Richard I.

AU - Jones, David R.

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AU - Putnam, Joe B.

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