Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer

Lavinia Gerdan, Barbara Šegedin, Theo Veninga, Steven E. Schild, Dirk Rades

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Aim: To investigate the prognostic role of the number of involved extracranial organs in patients with brain metastasis from small-cell lung cancer (SCLC). Patients and Methods: Data of 155 patients receiving wholebrain radiotherapy (WBRT) alone for brain metastasis from SCLC were retrospectively evaluated. In addition to the number of involved extracranial organs, six potential prognostic factors were analyzed including WBRT regimen, age, gender, Karnofsky performance score (KPS), number of brain metastases, and interval from diagnosis of SCLC to WBRT. Results: Six-month survival rates of patients with involvement of 0, 1, 2, and ≥3 extracranial organs were 52%, 29%, 9%, and 0%, respectively (p<0.001). On multivariate analysis, the number of involved extracranial organs remained significant (p=0.003). Older age (p=0.005), lower KPS (p<0.001), and greater number of brain metastases (p=0.005) were also significantly associated with poorer survival. Conclusion: The number of involved extracranial organs is an independent prognostic factor of survival in SCLC patients with brain metastasis.

Original languageEnglish (US)
Pages (from-to)3887-3890
Number of pages4
JournalAnticancer Research
Volume33
Issue number9
StatePublished - Sep 2013

Fingerprint

Tissue Survival
Small Cell Lung Carcinoma
Neoplasm Metastasis
Brain
Radiotherapy
Survival
Multivariate Analysis
Survival Rate

Keywords

  • Brain metastasis
  • Extracranial organs
  • Prognostic factors
  • SCLC
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gerdan, L., Šegedin, B., Veninga, T., Schild, S. E., & Rades, D. (2013). Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer. Anticancer Research, 33(9), 3887-3890.

Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer. / Gerdan, Lavinia; Šegedin, Barbara; Veninga, Theo; Schild, Steven E.; Rades, Dirk.

In: Anticancer Research, Vol. 33, No. 9, 09.2013, p. 3887-3890.

Research output: Contribution to journalArticle

Gerdan, L, Šegedin, B, Veninga, T, Schild, SE & Rades, D 2013, 'Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer', Anticancer Research, vol. 33, no. 9, pp. 3887-3890.
Gerdan, Lavinia ; Šegedin, Barbara ; Veninga, Theo ; Schild, Steven E. ; Rades, Dirk. / Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer. In: Anticancer Research. 2013 ; Vol. 33, No. 9. pp. 3887-3890.
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