TY - JOUR
T1 - Number of extraspinal organs with metastases
T2 - A prognostic factor of survival in patients with metastatic spinal cord compression (MSCC) from Non-small Cell Lung Cancer (NSCLC)
AU - Rades, Dirk
AU - Weber, Axel
AU - Karstens, Johann H.
AU - Schild, Steven E.
AU - Bartscht, Tobias
PY - 2014/5/1
Y1 - 2014/5/1
N2 - Background/Aim: In patients irradiated for MSCC from NSCLC, the number of extraspinal organs involved by metastases was investigated for associations with survival. Patients and Methods: The data of 131 patients irradiated with 10?3 Gy in two weeks for MSCC were evaluated. The number of involved extraspinal organs plus eight other factors were retrospectively analyzed. Results: The 6-month survival rates were 72%, 57%, 20%, and 11% for the involvement of 0, 1, 2, and?3 extraspinal organs, respectively (p<0.001). On multivariate analysis, the number of involved extraspinal organs remained significant (risk ratio 1.60; 95% CI 1.28-2.00; p<0.001). Gender (p=0.028), ECOG performance score (p=0.001), histology (p=0.014), ambulatory status (p=0.002), and time to developing motor deficits (p=0.041) were also independent prognostic factors for survival. Conclusion: The number of extraspinal organs with metastases is an independent prognostic factor for the survival of NSCLC patients presenting with MSCC and should be considered in future studies.
AB - Background/Aim: In patients irradiated for MSCC from NSCLC, the number of extraspinal organs involved by metastases was investigated for associations with survival. Patients and Methods: The data of 131 patients irradiated with 10?3 Gy in two weeks for MSCC were evaluated. The number of involved extraspinal organs plus eight other factors were retrospectively analyzed. Results: The 6-month survival rates were 72%, 57%, 20%, and 11% for the involvement of 0, 1, 2, and?3 extraspinal organs, respectively (p<0.001). On multivariate analysis, the number of involved extraspinal organs remained significant (risk ratio 1.60; 95% CI 1.28-2.00; p<0.001). Gender (p=0.028), ECOG performance score (p=0.001), histology (p=0.014), ambulatory status (p=0.002), and time to developing motor deficits (p=0.041) were also independent prognostic factors for survival. Conclusion: The number of extraspinal organs with metastases is an independent prognostic factor for the survival of NSCLC patients presenting with MSCC and should be considered in future studies.
KW - Extraspinal involvement
KW - Metastatic spinal cord compression
KW - Non-small cell lung cancer
KW - Prognostic factors
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84902957327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902957327&partnerID=8YFLogxK
M3 - Article
C2 - 24778067
AN - SCOPUS:84902957327
SN - 0250-7005
VL - 34
SP - 2503
EP - 2508
JO - Anticancer research
JF - Anticancer research
IS - 5
ER -