Nuclear transport: Target for therapy

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Drugs directed at plasma membrane receptors target environment-cell interactions and are the mainstay of clinical pharmacology. Decoding mechanisms that govern intracellular signaling has recently opened new therapeutic avenues for interventions at cytosol-organellar interfaces. The nuclear envelope and nuclear transport machinery have emerged central in the discovery and development of experimental therapeutics capable of modulating cellular genetic programs. Insight into nucleocytoplasmic exchange has unmasked promising anticancer, antiviral, and anti-inflammatory strategies.

Original languageEnglish (US)
Pages (from-to)880-886
Number of pages7
JournalClinical pharmacology and therapeutics
Volume81
Issue number6
DOIs
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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