Nuclear structure--skeletal gene expression interrelationships.

G. S. Stein, A. J. van Wijnen, J. L. Stein, J. B. Lian

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Using the osteocalcin gene as a paradigm for bone tissue-specific transcription, evidence is presented for functional linkage of nuclear architecture with developmental and steroid hormone-responsive control. The involvement of chromatin structure, nucleosome organization and the nuclear matrix is evaluated within the context of integrating regulatory signals that activate and/or suppress transcription of the osteocalcin gene. Mechanisms are evaluated which direct the bone and hematopoietic-specific acute myelogenous leukemia/core binding factor (AML/CBF) transcription factors to nuclear matrix-associated subnuclear domains that are competent to support expression.

Original languageEnglish (US)
Pages (from-to)d849-864
JournalFrontiers in bioscience : a journal and virtual library
Volume3
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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