Nuclear structure-gene expression interrelationships: Implications for aberrant gene expression in cancer

Gary S. Stein, Martin Montecino, André J. Van Wijnen, Janet L. Stein, Jane B. Lian

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

There is long-standing recognition that transformed and tumor cells exhibit striking alterations in nuclear morphology as well as in the representation and intranuclear distribution of nucleic acids and regulatory factors. Parameters of nuclear structure support cell growth and phenotypic properties of cells by facilitating the organization of genes, replication and transcription sites, chromatin remodeling complexes, transcripts, and regulatory factors in structurally and functionally definable subnuclear domains within the three-dimensional context of nuclear architecture. The emerging evidence for functional interrelationships of nuclear structure and gene expression is consistent with linkage of tumor-related modifications in nuclear organization to compromised gene regulation during the onset and progression of cancer.

Original languageEnglish (US)
Pages (from-to)2067-2076
Number of pages10
JournalCancer research
Volume60
Issue number8
StatePublished - Apr 15 2000

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Nuclear structure-gene expression interrelationships: Implications for aberrant gene expression in cancer'. Together they form a unique fingerprint.

  • Cite this

    Stein, G. S., Montecino, M., Van Wijnen, A. J., Stein, J. L., & Lian, J. B. (2000). Nuclear structure-gene expression interrelationships: Implications for aberrant gene expression in cancer. Cancer research, 60(8), 2067-2076.