Nuclear microenvironments support physiological control of gene expression

Gary S. Stein, Jane B. Lian, Martin Montecino, Janet L. Stein, André J. Van Wijnen, Amjad Javed, Jitesh Pratap, Je Choi, S. Kaleem Zaidi, Soraya Gutierrez, Kimberly Harrington, Jiali Shen, Daniel Young, Shirwin Pockwinse

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.

Original languageEnglish (US)
Pages (from-to)527-536
Number of pages10
JournalChromosome Research
Volume11
Issue number5
DOIs
StatePublished - Sep 5 2003

Keywords

  • Cell nucleus
  • Chromatin
  • Gene expression
  • Nucleosome
  • Osteocalcin
  • RUNX proteins

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Nuclear microenvironments support physiological control of gene expression'. Together they form a unique fingerprint.

  • Cite this

    Stein, G. S., Lian, J. B., Montecino, M., Stein, J. L., Van Wijnen, A. J., Javed, A., Pratap, J., Choi, J., Zaidi, S. K., Gutierrez, S., Harrington, K., Shen, J., Young, D., & Pockwinse, S. (2003). Nuclear microenvironments support physiological control of gene expression. Chromosome Research, 11(5), 527-536. https://doi.org/10.1023/A:1024943214431