Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation

Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Amjad Javed, Martin Montecino, S. Kaleem Zaidi, Daniel Young, Je Yong Choi, Soraya Gutierrez, Shirwin Pockwinse

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The temporal and spatial organization of transcriptional regulatory machinery provides microenvironments within the nucleus where threshold concentrations of genes and cognate factors facilitate functional interactions. Conventional biochemical, molecular, and in vivo genetic approaches, together with high throughput genomic and proteomic analysis are rapidly expanding our database of regulatory macromolecules and signaling pathways that are requisite for control of genes that govern proliferation and differentiation. There is accruing insight into the architectural organization of regulatory machinery for gene expression that suggests signatures for biological control. Localized scaffolding of regulatory macromolecules at strategic promoter sites and focal compartmentalization of genes, transcripts, and regulatory factors within intranuclear microenvironments provides an infrastructure for combinatorial control of transcription that is operative within the three dimensional context of nuclear architecture.

Original languageEnglish (US)
Pages (from-to)287-302
Number of pages16
JournalJournal of cellular biochemistry
Volume91
Issue number2
DOIs
StatePublished - 2004

Keywords

  • Gene expression
  • Nuclear architecture
  • Proliferation/differentiation
  • Regulatory factors
  • Signaling pathways
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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