Nuclear microenvironments: An architectural platform for the convergence and integration of transcriptional regulatory signals

Gary S. Stein, J. L. Stein, J. B. Lian, A. J. Van Wijnen, M. Montecino, A. Javed, S. K. Zaidi, D. Young, Je Yong Choi, S. Pockwinse

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Functional interrelationships between the intranuclear organization of nucleic acids and regulatory proteins are obligatory for fidelity of transcriptional activation and repression. In this article, using the Runx/AML/Cbfa transcription factors as a paradigm for linkage between nuclear structure and gene expression we present an overview of growing insight into the dynamic organization and assembly of regulatory machinery for gene expression at microenvironments within the nucleus. We address contributions of nuclear microenvironments to the convergence and integration of regulatory signals that mediate transcription by supporting the combinatorial assembly of regulatory complexes.

Original languageEnglish (US)
Pages (from-to)65-76
Number of pages12
JournalEuropean Journal of Histochemistry
Volume48
Issue number1
StatePublished - 2004

Keywords

  • BMP/TGFβ
  • Chromatin
  • Gene regulation
  • Mitotic partitioning
  • Osteocalcin
  • Runx/AML/Cbfa
  • Transcription complexes

ASJC Scopus subject areas

  • Biophysics
  • Histology
  • Cell Biology

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