Nuclear ion channels and regulation of the nuclear pore.

L. Stehno-Bittel, C. Perez-Terzic, A. Luckhoff, D. E. Clapham

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Multiple K+, Cl-, and nonselective cationic nuclear channels have been identified in a variety of cell types from coconut endosperm to cardiac myocytes. To date, only one ligand-gated nuclear channel has been characterized-the InsP3R-but it is likely that others are also present. The InsP3R channel has been implicated in two important nuclear events: (1) nuclear vesicle fusion (Sullivan et al., 1993) and (2) regulation of molecular transport through the nuclear pore (Stehno-Bittel et al., 1993) and (2) 1995b). Regulation of passive diffusion across the nuclear envelope by the nuclear Ca2+ store may play an important role in nuclear events ranging from apoptosis to cell division.

Original languageEnglish (US)
Pages (from-to)195-207
Number of pages13
JournalSociety of General Physiologists series
Volume51
StatePublished - 1996

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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