NT69L blocks ethanol-induced increase of dopamine and glutamate levels in striatum of mouse

Zhimin Li, Mona Boules, Elliott Richelson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Recent study shows that NT69L, an analog of neurotensin (NT) (8-13), reduces ethanol consumption and preference in mice through modulation of neurotensin receptor subtype one. The current study showed that NT69L significantly decreased ethanol-induced increase of dopamine and glutamate levels in striatum of mouse. These data suggest that NT69L prevents ethanol consumption through the modulation of both dopaminergic and glutamatergic systems implicated in ethanol addiction. NT agonists may provide novel treatment for alcohol addiction.

Original languageEnglish (US)
Pages (from-to)322-324
Number of pages3
JournalNeuroscience Letters
Volume487
Issue number3
DOIs
StatePublished - Jan 10 2011

Keywords

  • Dopamine
  • Ethanol
  • Glutamate
  • NT69L
  • Neurotensin
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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