Novelty seeking and introversion do not predict the long-term risk of Parkinson disease

G. Arabia, B. R. Grossardt, R. C. Colligan, James Howard Bower, D. M. Maraganore, J. E. Ahlskog, Yonas Endale Geda, Walter A Rocca

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Abstract

OBJECTIVE: It has been suggested that people who develop Parkinson disease (PD) may have a characteristic premorbid personality. We tested this hypothesis using a large historical cohort study with long follow-up. METHODS: We conducted a historical cohort study in the region including the 120-mile radius centered in Rochester, MN. We recruited 7,216 subjects who completed the Minnesota Multiphasic Personality Inventory (MMPI) for research at the Mayo Clinic from 1962 through 1965 and we considered 5 MMPI scales to measure sensation seeking, hypomania, positive emotionality, social introversion, and constraint. A total of 6,822 subjects (94.5% of the baseline sample) were followed over 4 decades either actively (via interview and examination) or passively (via medical records). RESULTS: During follow-up, 227 subjects developed parkinsonism (156 developed PD). The 3 MMPI scales that we selected to measure the extroverted personality construct (sensation seeking, hypomania, and positive emotionality) did not show the expected pattern of higher scores associated with reduced risk of PD. Similarly, the 2 MMPI scales that we selected to measure the introverted personality construct (social introversion and constraint) did not show the expected pattern of higher scores associated with increased risk of PD. However, higher scores for constraint were associated with an increased risk of all types of parkinsonism pooled together (hazard ratio 1.39; 95% CI 1.06-1.84; p = 0.02). CONCLUSIONS: We suggest that personality traits related to introversion and extroversion do not predict the risk of PD.

Original languageEnglish (US)
Pages (from-to)349-357
Number of pages9
JournalNeurology
Volume75
Issue number4
DOIs
StatePublished - Jul 27 2010

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MMPI
Parkinson Disease
Personality
Parkinsonian Disorders
Cohort Studies
Medical Records
Introversion (Psychology)
Interviews
Research

ASJC Scopus subject areas

  • Clinical Neurology

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Novelty seeking and introversion do not predict the long-term risk of Parkinson disease. / Arabia, G.; Grossardt, B. R.; Colligan, R. C.; Bower, James Howard; Maraganore, D. M.; Ahlskog, J. E.; Geda, Yonas Endale; Rocca, Walter A.

In: Neurology, Vol. 75, No. 4, 27.07.2010, p. 349-357.

Research output: Contribution to journalArticle

Arabia G, Grossardt BR, Colligan RC, Bower JH, Maraganore DM, Ahlskog JE et al. Novelty seeking and introversion do not predict the long-term risk of Parkinson disease. Neurology. 2010 Jul 27;75(4):349-357. https://doi.org/10.1212/WNL.0b013e3181ea15fd
Arabia, G. ; Grossardt, B. R. ; Colligan, R. C. ; Bower, James Howard ; Maraganore, D. M. ; Ahlskog, J. E. ; Geda, Yonas Endale ; Rocca, Walter A. / Novelty seeking and introversion do not predict the long-term risk of Parkinson disease. In: Neurology. 2010 ; Vol. 75, No. 4. pp. 349-357.
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