TY - JOUR
T1 - Novel use of levodopa in human immunodeficiency virus encephalopathy-mediated parkinsonism in an adult
AU - Devine, M.
AU - Herrin, C.
AU - Warnack, W.
AU - Dubey, D.
N1 - Publisher Copyright:
© 2018 Journal of Postgraduate Medicine.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - We report a case of a 36-year-old man with a medical history of human immunodeficiency virus (HIV) infection who presented with hypomimia, hypophonia, bradykinesia, rigidity, and freezing of gait. His clinical presentation and magnetic resonance imaging were consistent with HIV encephalopathy with involvement of the bilateral basal ganglia and diffuse leukoencephalopathy. We initiated a trial of carbidopa-levodopa. The dose was escalated to 1050 mg levodopa daily. Amantadine was also started. The patient was closely monitored for behavioral, neurological, or systemic side effects. He tolerated therapy well without adverse effects. The patient's neurological status significantly improved with levodopa, including hypomimia, hypophonia, bradykinesia, and fluidity of gait. This case demonstrates that carbidopa-levodopa can be safely utilized to manage parkinsonism in an adult patient with HIV encephalopathy.
AB - We report a case of a 36-year-old man with a medical history of human immunodeficiency virus (HIV) infection who presented with hypomimia, hypophonia, bradykinesia, rigidity, and freezing of gait. His clinical presentation and magnetic resonance imaging were consistent with HIV encephalopathy with involvement of the bilateral basal ganglia and diffuse leukoencephalopathy. We initiated a trial of carbidopa-levodopa. The dose was escalated to 1050 mg levodopa daily. Amantadine was also started. The patient was closely monitored for behavioral, neurological, or systemic side effects. He tolerated therapy well without adverse effects. The patient's neurological status significantly improved with levodopa, including hypomimia, hypophonia, bradykinesia, and fluidity of gait. This case demonstrates that carbidopa-levodopa can be safely utilized to manage parkinsonism in an adult patient with HIV encephalopathy.
KW - AIDS dementia complex
KW - gait apraxia
KW - human immunodeficiency virus
KW - levodopa
KW - parkinsonian disorder
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U2 - 10.4103/jpgm.JPGM_674_16
DO - 10.4103/jpgm.JPGM_674_16
M3 - Article
C2 - 28862245
AN - SCOPUS:85041458286
SN - 0022-3859
VL - 64
SP - 53
EP - 55
JO - Journal of Postgraduate Medicine
JF - Journal of Postgraduate Medicine
IS - 1
ER -