TY - JOUR
T1 - Novel Treatment Strategies in the Management of Waldenström Macroglobulinemia
AU - Zanwar, Saurabh
AU - Abeykoon, Jithma Prasad
AU - Kapoor, Prashant
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Purpose of Review: Recent advances the genomic profiling of patients with Waldenström macroglobulinemia (WM) have led to the identification of novel therapeutic targets in these patients. In this review, we cover the current standard of care and the recently evaluated novel approaches with high potential to be incorporated in the therapeutic armamentarium against WM. Recent Findings: The MYD88L265P mutation is the most common genomic abnormality in WM, and is encountered in 80–95% of patients, making it an important target for drug development. The success of the first-generation Bruton tyrosine kinase (BTK) inhibitor, ibrutinib, has generated tremendous interest in the study of more selective and potent BTK inhibitors. Additionally, the identification of CXCR4WHIM mutations in up to approximately 40% of patients with WM has fueled research regarding their implication on systemic therapy in WM. Summary: In a rapidly advancing field of targeted therapies, the treatment options for patients with WM are expanding as researchers continue to uncover and harness the survival pathways active in this hematologic malignancy.
AB - Purpose of Review: Recent advances the genomic profiling of patients with Waldenström macroglobulinemia (WM) have led to the identification of novel therapeutic targets in these patients. In this review, we cover the current standard of care and the recently evaluated novel approaches with high potential to be incorporated in the therapeutic armamentarium against WM. Recent Findings: The MYD88L265P mutation is the most common genomic abnormality in WM, and is encountered in 80–95% of patients, making it an important target for drug development. The success of the first-generation Bruton tyrosine kinase (BTK) inhibitor, ibrutinib, has generated tremendous interest in the study of more selective and potent BTK inhibitors. Additionally, the identification of CXCR4WHIM mutations in up to approximately 40% of patients with WM has fueled research regarding their implication on systemic therapy in WM. Summary: In a rapidly advancing field of targeted therapies, the treatment options for patients with WM are expanding as researchers continue to uncover and harness the survival pathways active in this hematologic malignancy.
KW - BTK inhibitors
KW - CXCR4
KW - IgM lymphoplasmacytic lymphoma
KW - MYD88
KW - Non-Hodgkin lymphoma
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U2 - 10.1007/s11899-020-00559-4
DO - 10.1007/s11899-020-00559-4
M3 - Review article
C2 - 32006301
AN - SCOPUS:85078917893
SN - 1558-8211
VL - 15
SP - 31
EP - 43
JO - Current Hematologic Malignancy Reports
JF - Current Hematologic Malignancy Reports
IS - 1
ER -