Novel therapeutic options in primary systemic amyloidosis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Amyloid is defined in tissue sections as an amorphous deposit that binds the dye Congo red and demonstrates apple-green birefringence when viewed under polarized light. X-ray diffraction studies have shown that the binding of Congo red is due to the ß-pleated sheet configuration of the amyloid protein. All amyloid deposits are extracellular, and the clinical syndrome resulting from the deposition of amyloid is termed amyloidosis. This chapter discusses amyloidosis related to immunoglobulin light-chain deposits (AL amyloidosis) and current therapies directed at the management of this type of amyloidosis (1).

Original languageEnglish (US)
Title of host publicationMultiple Myeloma
Subtitle of host publicationTranslational and Emerging Therapies
PublisherCRC Press
Pages261-276
Number of pages16
ISBN (Electronic)9781420045116
ISBN (Print)9781420045109
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Medicine(all)

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