Novel Therapeutic Approaches for Acute Lymphoblastic Leukemia

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Success in therapy for adults with acute lymphoblastic leukemia (ALL) has lagged behind that of children with ALL. However, the application of pediatric-intensive regimens to young and middle-aged adults suggests improved outcomes without excessive toxicity. A promising area in the treatment of adult ALL is the addition of monoclonal antibodies in various forms to chemotherapy in adults with ALL. New chemotherapeutic approaches show promise, and early-phase clinical trials with these drugs are under way.

Original languageEnglish (US)
Pages (from-to)1303-1317
Number of pages15
JournalHematology/Oncology Clinics of North America
Volume25
Issue number6
DOIs
StatePublished - Dec 1 2011

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Keywords

  • Acute lymphoblastic leukemia
  • Chemotherapy
  • Kinase inhibitor therapy
  • Monoclonal antibody therapy

ASJC Scopus subject areas

  • Hematology
  • Oncology

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