Novel Therapeutic Approaches for Acute Lymphoblastic Leukemia

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Success in therapy for adults with acute lymphoblastic leukemia (ALL) has lagged behind that of children with ALL. However, the application of pediatric-intensive regimens to young and middle-aged adults suggests improved outcomes without excessive toxicity. A promising area in the treatment of adult ALL is the addition of monoclonal antibodies in various forms to chemotherapy in adults with ALL. New chemotherapeutic approaches show promise, and early-phase clinical trials with these drugs are under way.

Original languageEnglish (US)
Pages (from-to)1303-1317
Number of pages15
JournalHematology/Oncology Clinics of North America
Volume25
Issue number6
DOIs
StatePublished - Dec 1 2011

Keywords

  • Acute lymphoblastic leukemia
  • Chemotherapy
  • Kinase inhibitor therapy
  • Monoclonal antibody therapy

ASJC Scopus subject areas

  • Hematology
  • Oncology

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