Novel Therapeutic Approaches for Acute Lymphoblastic Leukemia

Mark R. Litzow

doi:10.1016/j.hoc.2011.09.019

Novel Therapeutic Approaches for Acute Lymphoblastic Leukemia

Mark R. Litzow

Hematology

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Success in therapy for adults with acute lymphoblastic leukemia (ALL) has lagged behind that of children with ALL. However, the application of pediatric-intensive regimens to young and middle-aged adults suggests improved outcomes without excessive toxicity. A promising area in the treatment of adult ALL is the addition of monoclonal antibodies in various forms to chemotherapy in adults with ALL. New chemotherapeutic approaches show promise, and early-phase clinical trials with these drugs are under way.

Original language	English (US)
Pages (from-to)	1303-1317
Number of pages	15
Journal	Hematology/Oncology Clinics of North America
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.hoc.2011.09.019
State	Published - Dec 2011

Keywords

Acute lymphoblastic leukemia
Chemotherapy
Kinase inhibitor therapy
Monoclonal antibody therapy

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.hoc.2011.09.019

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abstract = "Success in therapy for adults with acute lymphoblastic leukemia (ALL) has lagged behind that of children with ALL. However, the application of pediatric-intensive regimens to young and middle-aged adults suggests improved outcomes without excessive toxicity. A promising area in the treatment of adult ALL is the addition of monoclonal antibodies in various forms to chemotherapy in adults with ALL. New chemotherapeutic approaches show promise, and early-phase clinical trials with these drugs are under way.",

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AB - Success in therapy for adults with acute lymphoblastic leukemia (ALL) has lagged behind that of children with ALL. However, the application of pediatric-intensive regimens to young and middle-aged adults suggests improved outcomes without excessive toxicity. A promising area in the treatment of adult ALL is the addition of monoclonal antibodies in various forms to chemotherapy in adults with ALL. New chemotherapeutic approaches show promise, and early-phase clinical trials with these drugs are under way.

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KW - Chemotherapy

KW - Kinase inhibitor therapy

KW - Monoclonal antibody therapy

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Novel Therapeutic Approaches for Acute Lymphoblastic Leukemia

Abstract

Keywords

ASJC Scopus subject areas

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