Novel strategies for nanoparticle-based radiosensitization in glioblastoma

Henry Ruiz-Garcia, Cristopher Ramirez-Loera, Timothy D. Malouff, Danushka S. Seneviratne, Joshua D. Palmer, Daniel M. Trifiletti

Research output: Contribution to journalReview articlepeer-review

Abstract

Radiotherapy (RT) is one of the cornerstones in the current treatment paradigm for glioblas-toma (GBM). However, little has changed in the management of GBM since the establishment of the current protocol in 2005, and the prognosis remains grim. Radioresistance is one of the hallmarks for treatment failure, and different therapeutic strategies are aimed at overcoming it. Among these strate-gies, nanomedicine has advantages over conventional tumor therapeutics, including improvements in drug delivery and enhanced antitumor properties. Radiosensitizing strategies using nanoparticles (NP) are actively under study and hold promise to improve the treatment response. We aim to describe the basis of nanomedicine for GBM treatment, current evidence in radiosensitization efforts using nanoparticles, and novel strategies, such as preoperative radiation, that could be synergized with nanoradiosensitizers.

Original languageEnglish (US)
Article number9673
JournalInternational journal of molecular sciences
Volume22
Issue number18
DOIs
StatePublished - Sep 2021

Keywords

  • Glioblastoma
  • Nanoparticle
  • Radiosensitization
  • Radiotherapy
  • Stem-cells
  • Theranostic

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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