Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis

Jason Kerkvliet, Ramakrishna Edukulla, Moses Rodriguez

Research output: Contribution to journalArticle

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Abstract

The RNA-dependent RNA-polymerase, 3 D pol, is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of 3 D pol in mice has antiviral effects. Here, we discuss the structure and function of 3 D pol during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in 3 D pol after picornavirus infection, highlight data showing the antiviral effects of transgenic 3 D pol from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which 3 D pol is causing this antiviral effect in mice.

Original languageEnglish (US)
Article number368068
JournalAdvances in Virology
Volume2010
DOIs
StatePublished - Dec 1 2010

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ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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