Novel risk factors for atherosclerosis

Iftikhar Jan Kullo, Gerald T. Gau, A. Jamil Tajik

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

In the past several years, evidence has accumulated that factors other than conventional risk factors may contribute to the development of atherosclerosis. Conventional risk factors predict less than one half of future cardiovascular events. Furthermore, conventional risk factors may not have the same causal effect in different ethnic groups in whom novel risk factors may have a role. These newer risk factors for atherosclerosis include homocysteine, fibrinogen, impaired fibrinolysis, increased platelet reactivity, hypercoagulability, lipoprotein(a), small dense low-density lipoprotein cholesterol, and inflammatory-infectious markers. Identification of other markers associated with an increased risk of atherosclerotic vascular disease may allow better insight into the pathobiology of atherosclerosis and facilitate the development of preventive and therapeutic measures. In this review, we discuss the evidence associating these factors in the pathogenesis of atherosclerosis, the mechanism of risk, and the clinical implications of this knowledge.

Original languageEnglish (US)
Pages (from-to)369-380
Number of pages12
JournalMayo Clinic Proceedings
Volume75
Issue number4
StatePublished - 2000

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Atherosclerosis
Lipoprotein(a)
Thrombophilia
Homocysteine
Fibrinolysis
Vascular Diseases
Ethnic Groups
LDL Cholesterol
Fibrinogen
Blood Platelets
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kullo, I. J., Gau, G. T., & Jamil Tajik, A. (2000). Novel risk factors for atherosclerosis. Mayo Clinic Proceedings, 75(4), 369-380.

Novel risk factors for atherosclerosis. / Kullo, Iftikhar Jan; Gau, Gerald T.; Jamil Tajik, A.

In: Mayo Clinic Proceedings, Vol. 75, No. 4, 2000, p. 369-380.

Research output: Contribution to journalArticle

Kullo, IJ, Gau, GT & Jamil Tajik, A 2000, 'Novel risk factors for atherosclerosis', Mayo Clinic Proceedings, vol. 75, no. 4, pp. 369-380.
Kullo IJ, Gau GT, Jamil Tajik A. Novel risk factors for atherosclerosis. Mayo Clinic Proceedings. 2000;75(4):369-380.
Kullo, Iftikhar Jan ; Gau, Gerald T. ; Jamil Tajik, A. / Novel risk factors for atherosclerosis. In: Mayo Clinic Proceedings. 2000 ; Vol. 75, No. 4. pp. 369-380.
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