Novel opportunities for computational biology and sociology in drug discovery

Lixia Yao, James A. Evans, Andrey Rzhetsky

Research output: Contribution to journalComment/debate

13 Citations (Scopus)

Abstract

Current drug discovery is impossible without sophisticated modeling and computation. In this review we outline previous advances in computational biology and, by tracing the steps involved in pharmaceutical development, explore a range of novel, high-value opportunities for computational innovation in modeling the biological process of disease and the social process of drug discovery. These opportunities include text mining for new drug leads, modeling molecular pathways and predicting the efficacy of drug cocktails, analyzing genetic overlap between diseases and predicting alternative drug use. Computation can also be used to model research teams and innovative regions and to estimate the value of academy-industry links for scientific and human benefit. Attention to these opportunities could promise punctuated advance and will complement the well-established computational work on which drug discovery currently relies.

Original languageEnglish (US)
Pages (from-to)161-170
Number of pages10
JournalTrends in Biotechnology
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

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Sociology
Drug Discovery
Computational Biology
Pharmaceutical Preparations
Biological Phenomena
Molecular modeling
Data Mining
Drug Design
Drug products
Industry
Innovation
Research

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

Cite this

Novel opportunities for computational biology and sociology in drug discovery. / Yao, Lixia; Evans, James A.; Rzhetsky, Andrey.

In: Trends in Biotechnology, Vol. 28, No. 4, 01.04.2010, p. 161-170.

Research output: Contribution to journalComment/debate

Yao, Lixia ; Evans, James A. ; Rzhetsky, Andrey. / Novel opportunities for computational biology and sociology in drug discovery. In: Trends in Biotechnology. 2010 ; Vol. 28, No. 4. pp. 161-170.
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