Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization

Paul Fredrickson, Mona Boules, Sally Yerbury, Elliott Richelson

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated in nicotine addiction. Previously, we showed that one of our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalBrain Research
Volume979
Issue number1-2
DOIs
StatePublished - Jul 25 2003

Keywords

  • NT69L
  • Neurotensin
  • Nicotine
  • Sensitization

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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