Novel mechanisms in the regulation of phosphorus homeostasis

Theresa Berndt, Rajiv Kumar

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Phosphorus plays a critical role in diverse biological processes, and, therefore, the regulation of phosphorus balance and homeostasis are critical to the well being of the organism. Changes in environmental, dietary, and serum concen trations of inorganic phosphorus are detected by sensors that elicit changes in cellular function and alter the efficiency by which phosphorus is conserved. Short-term, post-cibal responses that occur independently of hormones previously thought to be important in phosphorus homeostasis may play a larger role than previously appreciated in the regulation of phosphorus homeostasis. Several hormones and regulatory factors such as the vitamin D endocrine system, parathyroid hormone, and the phosphatonins (FGF-23, sFRP-4, MEPE) among others, may play a role only in the long-term regulation of phosphorus homeostasis. In this review, we discuss how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus.

Original languageEnglish (US)
Pages (from-to)17-25
Number of pages9
JournalPhysiology
Volume24
Issue number1
DOIs
StatePublished - Feb 2009

Fingerprint

Phosphorus
Homeostasis
Hormones
Biological Phenomena
Endocrine System
Parathyroid Hormone
Vitamin D
Phosphates
Serum

ASJC Scopus subject areas

  • Physiology

Cite this

Novel mechanisms in the regulation of phosphorus homeostasis. / Berndt, Theresa; Kumar, Rajiv.

In: Physiology, Vol. 24, No. 1, 02.2009, p. 17-25.

Research output: Contribution to journalArticle

Berndt, Theresa ; Kumar, Rajiv. / Novel mechanisms in the regulation of phosphorus homeostasis. In: Physiology. 2009 ; Vol. 24, No. 1. pp. 17-25.
@article{c8f65c36c9c145f282c2174b2ebed2f6,
title = "Novel mechanisms in the regulation of phosphorus homeostasis",
abstract = "Phosphorus plays a critical role in diverse biological processes, and, therefore, the regulation of phosphorus balance and homeostasis are critical to the well being of the organism. Changes in environmental, dietary, and serum concen trations of inorganic phosphorus are detected by sensors that elicit changes in cellular function and alter the efficiency by which phosphorus is conserved. Short-term, post-cibal responses that occur independently of hormones previously thought to be important in phosphorus homeostasis may play a larger role than previously appreciated in the regulation of phosphorus homeostasis. Several hormones and regulatory factors such as the vitamin D endocrine system, parathyroid hormone, and the phosphatonins (FGF-23, sFRP-4, MEPE) among others, may play a role only in the long-term regulation of phosphorus homeostasis. In this review, we discuss how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus.",
author = "Theresa Berndt and Rajiv Kumar",
year = "2009",
month = "2",
doi = "10.1152/physiol.00034.2008",
language = "English (US)",
volume = "24",
pages = "17--25",
journal = "Physiology",
issn = "1548-9213",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Novel mechanisms in the regulation of phosphorus homeostasis

AU - Berndt, Theresa

AU - Kumar, Rajiv

PY - 2009/2

Y1 - 2009/2

N2 - Phosphorus plays a critical role in diverse biological processes, and, therefore, the regulation of phosphorus balance and homeostasis are critical to the well being of the organism. Changes in environmental, dietary, and serum concen trations of inorganic phosphorus are detected by sensors that elicit changes in cellular function and alter the efficiency by which phosphorus is conserved. Short-term, post-cibal responses that occur independently of hormones previously thought to be important in phosphorus homeostasis may play a larger role than previously appreciated in the regulation of phosphorus homeostasis. Several hormones and regulatory factors such as the vitamin D endocrine system, parathyroid hormone, and the phosphatonins (FGF-23, sFRP-4, MEPE) among others, may play a role only in the long-term regulation of phosphorus homeostasis. In this review, we discuss how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus.

AB - Phosphorus plays a critical role in diverse biological processes, and, therefore, the regulation of phosphorus balance and homeostasis are critical to the well being of the organism. Changes in environmental, dietary, and serum concen trations of inorganic phosphorus are detected by sensors that elicit changes in cellular function and alter the efficiency by which phosphorus is conserved. Short-term, post-cibal responses that occur independently of hormones previously thought to be important in phosphorus homeostasis may play a larger role than previously appreciated in the regulation of phosphorus homeostasis. Several hormones and regulatory factors such as the vitamin D endocrine system, parathyroid hormone, and the phosphatonins (FGF-23, sFRP-4, MEPE) among others, may play a role only in the long-term regulation of phosphorus homeostasis. In this review, we discuss how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus.

UR - http://www.scopus.com/inward/record.url?scp=59849097605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59849097605&partnerID=8YFLogxK

U2 - 10.1152/physiol.00034.2008

DO - 10.1152/physiol.00034.2008

M3 - Article

VL - 24

SP - 17

EP - 25

JO - Physiology

JF - Physiology

SN - 1548-9213

IS - 1

ER -