Novel mechanisms in the regulation of phosphorus homeostasis

Theresa Berndt, Rajiv Kumar

Research output: Contribution to journalReview article

144 Scopus citations

Abstract

Phosphorus plays a critical role in diverse biological processes, and, therefore, the regulation of phosphorus balance and homeostasis are critical to the well being of the organism. Changes in environmental, dietary, and serum concen trations of inorganic phosphorus are detected by sensors that elicit changes in cellular function and alter the efficiency by which phosphorus is conserved. Short-term, post-cibal responses that occur independently of hormones previously thought to be important in phosphorus homeostasis may play a larger role than previously appreciated in the regulation of phosphorus homeostasis. Several hormones and regulatory factors such as the vitamin D endocrine system, parathyroid hormone, and the phosphatonins (FGF-23, sFRP-4, MEPE) among others, may play a role only in the long-term regulation of phosphorus homeostasis. In this review, we discuss how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus.

Original languageEnglish (US)
Pages (from-to)17-25
Number of pages9
JournalPhysiology
Volume24
Issue number1
DOIs
StatePublished - Feb 1 2009

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ASJC Scopus subject areas

  • Physiology

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