Novel markers of peripheral arterial disease

Farhan J. Khawaja, Iftikhar J. Kullo

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Peripheral arterial disease (PAD), a relatively common manifestation of atherosclerotic vascular disease, is associated with significant morbidity and mortality. Although conventional risk factors contribute to the onset and progression of PAD, the role of 'novel' biomarkers in pathways of inflammation, thrombosis, lipoprotein metabolism, and oxidative stress in determining susceptibility to PAD is being increasingly recognized. Validation of novel risk factors for PAD may allow earlier detection, an improved understanding of disease etiology and progression, and the development of new therapies. In this review, we discuss available evidence for associations between novel circulating markers and several aspects of PAD including disease susceptibility, progression, functional limitation, and adverse outcomes.

Original languageEnglish (US)
Pages (from-to)381-392
Number of pages12
JournalVascular Medicine
Volume14
Issue number4
DOIs
StatePublished - 2009

Keywords

  • Inflammation
  • Peripheral arterial disease
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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