Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

Zaineb A F Albayati, Manjula Sunkara, Suzannah M. Schmidt-Malan, Melissa J. Karau, Andrew J. Morris, James M. Steckelberg, Robin Patel, Philip J. Breen, Mark S. Smeltzer, K. Grant Taylor, Kevyn E. Merten, William M. Pierce, Peter A. Crooks

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.

Original languageEnglish (US)
Pages (from-to)1855-1868
Number of pages14
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Vancomycin
Bone and Bones
Debridement
Durapatite
Intravenous Administration
Pharmacokinetics
Therapeutics
Infection

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Albayati, Z. A. F., Sunkara, M., Schmidt-Malan, S. M., Karau, M. J., Morris, A. J., Steckelberg, J. M., ... Crooks, P. A. (2016). Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrobial Agents and Chemotherapy, 60(3), 1855-1868. https://doi.org/10.1128/AAC.01609-15

Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. / Albayati, Zaineb A F; Sunkara, Manjula; Schmidt-Malan, Suzannah M.; Karau, Melissa J.; Morris, Andrew J.; Steckelberg, James M.; Patel, Robin; Breen, Philip J.; Smeltzer, Mark S.; Taylor, K. Grant; Merten, Kevyn E.; Pierce, William M.; Crooks, Peter A.

In: Antimicrobial Agents and Chemotherapy, Vol. 60, No. 3, 01.03.2016, p. 1855-1868.

Research output: Contribution to journalArticle

Albayati, ZAF, Sunkara, M, Schmidt-Malan, SM, Karau, MJ, Morris, AJ, Steckelberg, JM, Patel, R, Breen, PJ, Smeltzer, MS, Taylor, KG, Merten, KE, Pierce, WM & Crooks, PA 2016, 'Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone', Antimicrobial Agents and Chemotherapy, vol. 60, no. 3, pp. 1855-1868. https://doi.org/10.1128/AAC.01609-15
Albayati ZAF, Sunkara M, Schmidt-Malan SM, Karau MJ, Morris AJ, Steckelberg JM et al. Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrobial Agents and Chemotherapy. 2016 Mar 1;60(3):1855-1868. https://doi.org/10.1128/AAC.01609-15
Albayati, Zaineb A F ; Sunkara, Manjula ; Schmidt-Malan, Suzannah M. ; Karau, Melissa J. ; Morris, Andrew J. ; Steckelberg, James M. ; Patel, Robin ; Breen, Philip J. ; Smeltzer, Mark S. ; Taylor, K. Grant ; Merten, Kevyn E. ; Pierce, William M. ; Crooks, Peter A. / Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. In: Antimicrobial Agents and Chemotherapy. 2016 ; Vol. 60, No. 3. pp. 1855-1868.
@article{e288b99daef843e6953a9cea8b64feee,
title = "Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone",
abstract = "We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.",
author = "Albayati, {Zaineb A F} and Manjula Sunkara and Schmidt-Malan, {Suzannah M.} and Karau, {Melissa J.} and Morris, {Andrew J.} and Steckelberg, {James M.} and Robin Patel and Breen, {Philip J.} and Smeltzer, {Mark S.} and Taylor, {K. Grant} and Merten, {Kevyn E.} and Pierce, {William M.} and Crooks, {Peter A.}",
year = "2016",
month = "3",
day = "1",
doi = "10.1128/AAC.01609-15",
language = "English (US)",
volume = "60",
pages = "1855--1868",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "3",

}

TY - JOUR

T1 - Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

AU - Albayati, Zaineb A F

AU - Sunkara, Manjula

AU - Schmidt-Malan, Suzannah M.

AU - Karau, Melissa J.

AU - Morris, Andrew J.

AU - Steckelberg, James M.

AU - Patel, Robin

AU - Breen, Philip J.

AU - Smeltzer, Mark S.

AU - Taylor, K. Grant

AU - Merten, Kevyn E.

AU - Pierce, William M.

AU - Crooks, Peter A.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.

AB - We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.

UR - http://www.scopus.com/inward/record.url?scp=84960448629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960448629&partnerID=8YFLogxK

U2 - 10.1128/AAC.01609-15

DO - 10.1128/AAC.01609-15

M3 - Article

C2 - 26666918

AN - SCOPUS:84960448629

VL - 60

SP - 1855

EP - 1868

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 3

ER -