Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

Zaineb A.F. Albayati; Manjula Sunkara; Suzannah M. Schmidt-Malan; Melissa J. Karau; Andrew J. Morris; James M. Steckelberg; Robin Patel; Philip J. Breen; Mark S. Smeltzer; K. Grant Taylor; Kevyn E. Merten; William M. Pierce; Peter A. Crooks

doi:10.1128/AAC.01609-15

Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

Zaineb A.F. Albayati, Manjula Sunkara, Suzannah M. Schmidt-Malan, Melissa J. Karau, Andrew J. Morris, James M. Steckelberg, Robin Patel, Philip J. Breen, Mark S. Smeltzer, K. Grant Taylor, Kevyn E. Merten, William M. Pierce, Peter A. Crooks

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.

Original language	English (US)
Pages (from-to)	1855-1868
Number of pages	14
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01609-15
State	Published - Mar 1 2016

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Albayati, Z. A. F., Sunkara, M., Schmidt-Malan, S. M., Karau, M. J., Morris, A. J., Steckelberg, J. M., Patel, R., Breen, P. J., Smeltzer, M. S., Taylor, K. G., Merten, K. E., Pierce, W. M., & Crooks, P. A. (2016). Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrobial Agents and Chemotherapy, 60(3), 1855-1868. https://doi.org/10.1128/AAC.01609-15

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abstract = "We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.",

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AU - Sunkara, Manjula

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AU - Karau, Melissa J.

AU - Morris, Andrew J.

AU - Steckelberg, James M.

AU - Patel, Robin

AU - Breen, Philip J.

AU - Smeltzer, Mark S.

AU - Taylor, K. Grant

AU - Merten, Kevyn E.

AU - Pierce, William M.

AU - Crooks, Peter A.

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AB - We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancomycin. This suggests that BT-vancomycin may be a potential carrier for the systemic targeted delivery of vancomycin in the treatment of bone infections, potentially reducing the reliance on surgical debridement to achieve the desired therapeutic outcome.

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Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

Abstract

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