Novel balloon catheter device with pacing, ablating, electroporation, and drug-eluting capabilities for atrial fibrillation treatment - Preliminary efficacy and safety studies in a canine model

Christopher V. Desimone, Elisa Ebrille, Faisal F. Syed, Susan B. Mikell, Scott H. Suddendorf, Douglas Wahnschaffe, Dorothy J. Ladewig, Emily J. Gilles, Andrew J. Danielsen, David R. Holmes, Samuel J. Asirvatham

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Pulmonary vein isolation is an established therapeutic procedure for symptomatic atrial fibrillation (AF). This approach involves ablation of atrial tissue just outside the pulmonary veins. However, patient outcomes are limited because of a high rate of arrhythmia recurrence. Ablation of electrically active tissue inside the pulmonary vein may improve procedural success, but is currently avoided because of the complication of postablation stenosis. An innovative device that can ablate inside pulmonary veins and prevent stenosis is a viable strategy to increase long-term efficacy. We have developed a prototypical balloon catheter device capable of nonthermal pulmonary vein ablation along with elution of an antifibrotic agent intended to eliminate arrhythmogenic substrate without the risk of stenosis and have demonstrated its functionality in 4 acute canine experiments. Further optimization of this device may provide an innovative means to simultaneously ablate and prevent pulmonary vein stenosis for improved AF treatment in humans.

Original languageEnglish (US)
Pages (from-to)508-514
Number of pages7
JournalTranslational Research
Volume164
Issue number6
DOIs
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Biochemistry, medical
  • Physiology (medical)

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