Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated Infections

Paschalis Vergidis, Robin Patel

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

The pathogenesis of device-associated infections is related to biofilm bacteria that exhibit distinct characteristics with respect to growth rate, structural features, and protection from host immune mechanisms and antimicrobial agents when compared with planktonic counterparts. Biofilm-associated infections are prevented, diagnosed, and treated differently from infections not associated with biofilms. This article reviews innovative concepts for the prevention of biofilm formation, and novel treatment approaches. Specific approaches for the diagnosis and prevention of catheter-associated urinary tract and bloodstream infections, as well as infections associated with orthopedic implants and cardiovascular implantable electronic devices, are also discussed.

Original languageEnglish (US)
Pages (from-to)173-186
Number of pages14
JournalInfectious Disease Clinics of North America
Volume26
Issue number1
DOIs
StatePublished - Mar 2012

Keywords

  • Biofilm
  • Cardiovascular implantable electronic device infection
  • Catheter-associated bloodstream infection
  • Catheter-associated urinary tract infection
  • Medical device
  • Orthopedic implant infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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