Novel approaches to early detection of endometrial cancer

Madhu Bagaria, Emily Shields, Jamie N Bakkum-Gamez

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Purpose of review Detection of endometrial cancer at an early stage leads to better oncologic outcomes. To date, a screening test for endometrial cancer does not exist. Recent findings Evolving knowledge of molecular changes involved in endometrial cancer carcinogenesis paired with sensitive and high-throughput technological advancements are a promising combination that can be leveraged to detect tumor DNA and proteins. These molecular biomarkers can be identified in biospecimens collected via minimally invasive and noninvasive approaches. Exploiting lower genital tract secretions as a biospecimen also allows for patient self-sampling. Summary Successful development of a screening test for endometrial cancer using self-collected lower genital tract biospecimens has the potential to increase accessibility to care and improve patient compliance.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalCurrent Opinion in Obstetrics and Gynecology
Volume29
Issue number1
DOIs
StatePublished - 2017

Keywords

  • Biomarkers
  • DNA methylation
  • Endometrial cancer
  • Tampons

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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