Not a usual suspect; rabeprazole therapy presenting as a severe neuropsychiatric illness: Case report

Christopher A. Alfonzo, William V. Bobo, Myron D. Almond

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We report the case of a patient who, as a result of exposure to the proton pump inhibitor rabeprazole, developed a severe and disabling admixture of neuropsychiatric symptoms. Because of its widely appreciated placebo-like side effect profile, rabeprazole was never suspected as being the cause of his symptoms. Instead, a somatoform spectrum disorder was assigned based on the patient's atypical symptom presentation, progressive course, subjective psychological distress, intemperate consumption of healthcare resources over a relatively brief period of time and lack of any medical explanation for his symptoms at that time, despite exhaustive laboratory and radiologic work-ups. This case report reinforces the notion that even a medication such as rabeprazole, with an established safety and tolerability profile, may be associated with side effects severe enough to mimic disabling neuropsychiatric illness.

Original languageEnglish (US)
Pages (from-to)311-315
Number of pages5
JournalInternational Journal of Psychiatry in Medicine
Volume33
Issue number3
DOIs
StatePublished - Dec 1 2003

Keywords

  • Adverse effects
  • Neuropsychiatric
  • Neuropsychological
  • Proton pump inhibitors
  • Rabeprazole
  • Somatoform

ASJC Scopus subject areas

  • Psychiatry and Mental health

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